Results 101 to 110 of about 279,658 (282)

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

Mesoscale functional connectivity of amygdala to the auditory and prefrontal cortex of macaque monkeys revealed by INS-fMRI

NeuroImage
Mammals rely heavily on their auditory system to perceive environmental threats, socially communicate, and care for the young. As an extension of the multiple sensory system including the auditory system, the amygdala evaluates the emotional salience of ...
Qianbing Li, An Ping, Yuqi Feng, Bin Xu, Baorong Zhang, Anna Wang Roe, Lixia Gao, Xinjian Li   +7 more
doaj   +1 more source

Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology

Annals of Neurology, EarlyView.
The neurologist cares for patients with complex chronic conditions that compromise their wellbeing. Many such disorders are poorly understood. Whereas for some, effective symptomatic treatments exist, for most we lack an understanding of the molecular and cellular bases for disease pathogenesis needed for discovering disease‐modifying treatments ...
Fadel Zeidan, Joseph D. Stern, William C. Mobley   +2 more
wiley   +1 more source

Amygdala [PDF]

European Neurology, 2008
openaire   +3 more sources

Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease

Alzheimer’s Research & Therapy
Background The amygdala plays a role in behavior and emotional response and is vulnerable to Alzheimer’s disease (AD) pathology, yet little is known about amygdala tau accumulation before clinical symptom onset.
Catarina Tristão-Pereira, Stephanie Langella, Justin S. Sanchez, Vincent Malotaux, Bing He, Jorge Alcina, Jairo E. Martinez, Zoe Rubinstein, Ana Baena, Clara Vila-Castelar, Averi Giudicessi, Liliana Ramirez Gomez, Claudia Ramos, Daniel Vasquez, David Aguillon, Heidi I. L. Jacobs, Reisa A. Sperling, Keith Johnson, Jennifer R. Gatchel, Yakeel T. Quiroz   +19 more
doaj   +1 more source

MEG evidence for dynamic amygdala modulations by gaze and facial emotions.

PLoS ONE, 2013
BackgroundAmygdala is a key brain region for face perception. While the role of amygdala in the perception of facial emotion and gaze has been extensively highlighted with fMRI, the unfolding in time of amydgala responses to emotional versus neutral ...
Thibaud Dumas, Stéphanie Dubal, Yohan Attal, Marie Chupin, Roland Jouvent, Shasha Morel, Nathalie George   +6 more
doaj   +1 more source

Anatomical Progression of Neuropathology in FTLD‐TDP Type C and Linkage to Annexin A11

Annals of Neurology, EarlyView.
Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Allegra Kawles, Caroline Nelson, Ivan Ayala, Elena Barbieri, Rudolph Castellani, Changiz Geula, Tamar Gefen, M. Marsel Mesulam   +7 more
wiley   +1 more source

Robust automated amygdala segmentation via multi-atlas diffeomorphic registration

Frontiers in Neuroscience, 2012
Here, we describe a novel method for volumetric segmentation of the amygdala from MRI images collected from 35 human subjects. This approach is adapted from open-source techniques employed previously with the hippocampus (Suh et al., 2011; Wang et al ...
Jamie eHanson, Jung eSuh, Brendon eNacewicz, Matt eSutterer, Amy eCayo, Diane eStodola, Cory eBurghy, Hongzhi eWang, Brian eAvants, Paul eYushkevich, Marilyn eEssex, Seth ePolllak, Richard J Davidson   +12 more
doaj   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, EarlyView.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

When scientific paradigms lead to tunnel vision: lessons from the study of fear

npj Science of Learning, 2017
For the past 30 years, research on the amygdala has largely focused on the genesis of defensive behaviors as its main function. This focus originated from early lesion studies and was supported by extensive anatomical, physiological, and pharmacological ...
Denis Paré, Gregory J. Quirk
doaj   +1 more source