Results 101 to 110 of about 12,396 (213)

Novel Pharmaceuticals in Appetite Regulation: Exploring emerging gut peptides and their pharmacological prospects

Pharmacology Research & Perspectives
Obesity, a global health challenge, necessitates innovative approaches for effective management. Targeting gut peptides in the development of anti‐obesity pharmaceuticals has already demonstrated significant efficacy.
Igor Rubinić, Marija Kurtov, Robert Likić   +2 more
doaj   +1 more source

Metabolites from Marine Macroorganisms of the Red Sea Acting as Promoters or Inhibitors of Amylin Aggregation

Biomolecules
Amylin is part of the endocrine pancreatic system that contributes to glycemic control, regulating blood glucose levels. However, human amylin has a high tendency to aggregate, forming isolated amylin deposits that are observed in patients with type 2 ...
Mawadda Alghrably, Mohamed A. Tammam, Aikaterini Koutsaviti, Vassilios Roussis, Xabier Lopez, Giulia Bennici, Abeer Sharfalddin, Hanan Almahasheer, Carlos M. Duarte, Abdul-Hamid Emwas, Efstathia Ioannou, Mariusz Jaremko   +11 more
doaj   +1 more source

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors

Nature Communications
Obesity is a major and increasingly prevalent chronic metabolic disease with numerous comorbidities. While recent incretin-based therapies have provided pharmaceutical inroads into treatment of obesity, there remains an ongoing need for additional ...
Jianjun Cao, Matthew J. Belousoff, Rachel M. Johnson, Peter Keov, Zamara Mariam, Giuseppe Deganutti, George Christopoulos, Caroline A. Hick, Steffen Reedtz-Runge, Tine Glendorf, Borja Ballarín-González, Kirsten Raun, Charles Bayly-Jones, Denise Wootten, Patrick M. Sexton   +14 more
doaj   +1 more source

Review of pramlintide as adjunctive therapy in treatment of type 1 and type 2 diabetes

Drug Design, Development and Therapy, 2008
Gina Ryan, Tim A Briscoe, Lynette JobeCollege of Pharmacy and Health Sciences, Mercer University, Atlanta, Georgia, USAAbstract: Pramlintide (Symlin®), a synthetic analog of a neurohormone amylin, was approved by the US Food and Drug ...
Tim A Briscoe, Lynette Jobe, Gina Ryan   +1 more
doaj  

Amylin [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +1 more source

Amylin as a Neuroendocrine Hormone

The Scientific World Journal, 2001
Andrew A. Young
doaj   +1 more source

Peripheral amylin modulation rebalances brain glycolysis and Tau-Ser214 phosphorylation via cAMP-PKA signaling. [PDF]

iScience
Davargaon RS, Verma N, Kotiya D, Leibold N, Velmurugan GV, Coburn H, Chen KC, Ruiz D, Corces V, Liu H, Kachroo P, Singh PK, Gentry MS, Despa S, Despa F.   +14 more
europepmc   +1 more source

Pancreatic amylin dynamically reconfigures distributed brain networks governing appetite regulation in mice. [PDF]

Mol Metab
Gezginer I, Mazzini G, Le Foll C, Kindler D, Lutz TA, Razansky D.   +5 more
europepmc   +1 more source

Diabetes, Protein Misfolding, and Heat Stress: Molecular Insights and Translational Perspectives. [PDF]

TH Open
Abreu MM, Spitz VH, Smadja DM.
europepmc   +1 more source

Inhibition of Human Amylin Aggregation: <i>In Silico</i> and <i>In Vitro</i> Studies. [PDF]

ACS Omega
Mizgalska K, Al-Aani U, Aljaidah Y, Panek D, Chaari A, Bajda M.   +5 more
europepmc   +1 more source