Results 81 to 90 of about 11,774 (158)

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

Journal of Neuroinflammation, 2017
Background Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology.
Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamandas   +8 more
doaj   +1 more source

Molecular Dynamics of Amylin Amyloid Single Beta-Sheet

Amyloidosis are metabolic conformational diseases caused by misfolding and aggregation of soluble proteins in insoluble fibrils which deposit squeezing out the functioning cells or block cell-to-cell connectivity.
Lapidus, Dmitrijs, Liepina, Inta, Czaplewsky, Cezary, Ventura, Salvador, Liwo, Adam   +4 more
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Amylin Receptor 1 Mutagenesis Revealed a Potential Role of Calcitonin Serine 29 in Receptor Interaction

Biomedicines
Background: The amylin receptor is a receptor for the peptide hormone amylin, and its activation is known to reduce body weight. The amylin receptor functions as a heterodimer complex that consists of the calcitonin receptor for peptide hormone ...
Hyeseon Song, Jaehyeok Jang, Minjae Park, Junsu Yun, Jeongwoo Jin, Sangmin Lee   +5 more
doaj   +1 more source

Detection of Amylin-β-amyloid Hetero-Oligomers by Enzyme-Linked Immunosorbent Assay

Bio-Protocol
Amylin is an amyloidogenic neuroendocrine hormone co-synthesized and co-secreted with insulin from the pancreas. It readily crosses the blood–brain barrier and synergistically forms mixed amyloid plaques with β-amyloid (Aβ) in brain parenchyma ...
Noah Leibold, Deepak Kotiya, Nirmal Verma, Florin Despa   +3 more
doaj   +1 more source

Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk

, 2008
Byron J Hoogwerf, Krupa B Doshi, Dima DiabDepartment of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, Cleveland, USAAbstract: Pramlintide is a synthetic version of the naturally occurring pancreatic peptide called amylin.
Byron J Hoogwerf, Dima Diab, Krupa B Doshi   +2 more
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Exploring the central region of amylin and its analogs aggregation: the influence of metal ions and residue substitutions

Frontiers in Chemistry
Human amylin (hIAPP) is found in the form of amyloid deposits within the pancreatic cells of nearly all patients diagnosed with type 2 diabetes mellitus (T2DM).
Mawadda Alghrably, Giulia Bennici, Gabriela Szczupaj, Gabriela Szczupaj, Noura Alasmael, Somayah Qutub, Batoul Maatouk, Kousik Chandra, Michal Nowakowski, Abdul-Hamid Emwas, Mariusz Jaremko   +10 more
doaj   +1 more source

Metabolites from Marine Macroorganisms of the Red Sea Acting as Promoters or Inhibitors of Amylin Aggregation

Biomolecules
Amylin is part of the endocrine pancreatic system that contributes to glycemic control, regulating blood glucose levels. However, human amylin has a high tendency to aggregate, forming isolated amylin deposits that are observed in patients with type 2 ...
Mawadda Alghrably, Mohamed A. Tammam, Aikaterini Koutsaviti, Vassilios Roussis, Xabier Lopez, Giulia Bennici, Abeer Sharfalddin, Hanan Almahasheer, Carlos M. Duarte, Abdul-Hamid Emwas, Efstathia Ioannou, Mariusz Jaremko   +11 more
doaj   +1 more source

Control of energy homeostasis by amylin [PDF]

, 2018
Amylin is an important control of nutrient fluxes because it reduces energy intake, modulates nutrient utilization by inhibiting postprandial glucagon secretion, and increases energy disposal by preventing compensatory decreases of energy expenditure in ...
Lutz, Thomas
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Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors

Nature Communications
Obesity is a major and increasingly prevalent chronic metabolic disease with numerous comorbidities. While recent incretin-based therapies have provided pharmaceutical inroads into treatment of obesity, there remains an ongoing need for additional ...
Jianjun Cao, Matthew J. Belousoff, Rachel M. Johnson, Peter Keov, Zamara Mariam, Giuseppe Deganutti, George Christopoulos, Caroline A. Hick, Steffen Reedtz-Runge, Tine Glendorf, Borja Ballarín-González, Kirsten Raun, Charles Bayly-Jones, Denise Wootten, Patrick M. Sexton   +14 more
doaj   +1 more source

Islet amyloid and human amylin mediated beta-cell death are dissociated in human amylin transgenic mice

, 2008
Islet amyloid and human amylin mediated beta-cell death are dissociated in human amylin transgenic ...
David Scott (13093551), Shivanand Reddy (19562218), Kerry Loomes (6619556), Chathurini Fernando (19562221), Phil L'Huillier (19562224), Shaoping Zhang (11401365), Garth Cooper (15397739), Anthony Phillips (9420971), Jacqueline Aitken (19562215), Ric Broadhurst (7785368)   +9 more
core