Results 71 to 80 of about 11,774 (158)

Renal Impairment Does Not Affect Pharmacokinetics, Safety or Tolerability of Zenagamtide

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8946-8954, October 2026.
ABSTRACT Aims Zenagamtide is a novel, unimolecular glucagon‐like peptide‐1 and amylin receptor agonist in development for weight management and Type 2 diabetes. This study investigated the pharmacokinetic (PK) properties, safety and tolerability of zenagamtide in participants with various degrees of renal impairment versus participants with normal ...
Lykke Ida Kaas Oldenburg, Sine Pfeiffer Haugaard, Tobias Karlsson, Victoria Kegel‐Hübner, Mahera Parwez, Christoffer Wiingaard, Anne Flint   +6 more
wiley   +1 more source

Human Amylin as a Novel Diagnostic Marker for Hypothyroidism in Iraqi Patients

مجلة بغداد للعلوم
Amylin is a peptide hormone that the pancreas cell secretes along with insulin.  As a neuroendocrine hormone that sends a specific signal to the brain, amylin is essential for maintaining homeostasis in the metabolism.
Duha Khalil Ibrahim, layla othman
doaj   +1 more source

Synthesis and aggregation dynamics of amylin. [PDF]

, 2012
Thesis (Ph.D.)-University of KwaZulu-Natal, Westville, 2012.Amylin is a 37 amino acid long peptide that aggregates into toxic oligomers and fibrils. Since amylin is secreted by and also acts on pancreatic beta cells, type II diabetes is classified as an ...
Pillay, Karen.
core   +1 more source

Effects of amylin on eating and adiposity

, 2012
Amylin's best investigated function is to reduce eating via a meal size effect by promoting meal-ending satiation. This effect seems to depend on an activation of specific area postrema neurons.
Lutz, Thomas A; https://orcid.org/
core   +1 more source

Amylin and its effects on glucose homeostasis

, 2011
The pancreatic hormone amylin is co-secreted with insulin by beta-cells in response to nutrient intake. Studies performed in experimental animals have provided evidence that amylin may have several effects associated with carbohydrate metabolism.

core   +2 more sources

Construction and Identification of a Breast Bioreactor for Human-Derived Hypoglycemic Protein Amylin

Life
The mammary gland of mammals can generate numerous bioactive proteins. To express the human amylin protein in the mammary glands of domestic animals, we engineered a transgenic mammary gland bioreactor. For this study, we produced transgenic mice through
Kongwei Huang, Xiuying Yan, Zhipeng Li, Fuhang Liu, Kuiqing Cui, Qingyou Liu   +5 more
doaj   +1 more source

Amylin in the Periphery II: An Updated Mini-Review

The Scientific World Journal, 2006
Amylin is a polypeptide that is cosecreted with insulin from the β cells of the pancreas. Therefore, in states of diabetes in which the β-cell mass is largely depleted or dysfunctional, insulin and amylin secretion are also lost or dysregulated.While the
Peter J. Wookey, Thomas A. Lutz, Sof Andrikopoulos   +2 more
doaj   +1 more source

pH Dependence of Amylin Fibrillization

, 2016
In type 2 diabetics, the hormone amylin misfolds into amyloid plaques implicated in the destruction of the pancreatic β-cells that make insulin and amylin.
Jessica M. Snell (1855342), Suman Jha (1855336), Stephen B. Daniels (1855345), Frederick W. Kolling (1855339), Andrei T. Alexandrescu (282504), Sarah R. Sheftic (1855351), Sharadrao M. Patil (1855348)   +6 more
core   +1 more source

Amylin reduces plasma glucagon concentration in cats [PDF]

, 2010
Pancreatic amylin plays an important role in the control of nutrient fluxes and is an established therapy in human diabetes as it reduces post-prandial glucagon secretion and slows gastric emptying.
Furrer, D, Reusch, Claudia E; https://orcid.org/, Kaufmann, K, Lutz, Thomas A; https://orcid.org/   +3 more
core   +1 more source

SURPASS‐CVOT and the Emerging Biology of Cardiometabolic Benefit

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8753-8756, October 2026.
Salvatore Corrao, Francesco Cosentino, Massimo Federici   +2 more
wiley   +1 more source