Results 71 to 80 of about 8,359 (180)

Amylin in the Periphery II: An Updated Mini-Review

The Scientific World Journal, 2006
Amylin is a polypeptide that is cosecreted with insulin from the β cells of the pancreas. Therefore, in states of diabetes in which the β-cell mass is largely depleted or dysfunctional, insulin and amylin secretion are also lost or dysregulated.While the
Peter J. Wookey, Thomas A. Lutz, Sof Andrikopoulos   +2 more
doaj   +1 more source

An edge β‐strand mutation turns ubiquitin into a pore‐forming amyloid

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Ubiquitin (Ub) is a highly conserved eukaryotic protein, generally regarded as stable and soluble under physiological conditions, playing a key role in maintaining cellular protein balance. Using complementary bioinformatic, biophysical, immunochemical, and electrophysiological approaches, we show that a single point mutation—the substitution ...
Daniela Meleleo, Rosanna Mallamaci, Vincenza Calò, Maurizio Losacco, Vincenzo Mangini, Fabio Arnesano   +5 more
wiley   +1 more source

Construction and Identification of a Breast Bioreactor for Human-Derived Hypoglycemic Protein Amylin

Life
The mammary gland of mammals can generate numerous bioactive proteins. To express the human amylin protein in the mammary glands of domestic animals, we engineered a transgenic mammary gland bioreactor. For this study, we produced transgenic mice through
Kongwei Huang, Xiuying Yan, Zhipeng Li, Fuhang Liu, Kuiqing Cui, Qingyou Liu   +5 more
doaj   +1 more source

Amylin [PDF]

, 2020
Chia-Lin Chuang, Debbie L. Hay
openaire   +2 more sources

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

Journal of Neuroinflammation, 2017
Background Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology.
Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamandas   +8 more
doaj   +1 more source

Detection of Amylin-β-amyloid Hetero-Oligomers by Enzyme-Linked Immunosorbent Assay

Bio-Protocol
Amylin is an amyloidogenic neuroendocrine hormone co-synthesized and co-secreted with insulin from the pancreas. It readily crosses the blood–brain barrier and synergistically forms mixed amyloid plaques with β-amyloid (Aβ) in brain parenchyma ...
Noah Leibold, Deepak Kotiya, Nirmal Verma, Florin Despa   +3 more
doaj   +1 more source

Exploring the central region of amylin and its analogs aggregation: the influence of metal ions and residue substitutions

Frontiers in Chemistry
Human amylin (hIAPP) is found in the form of amyloid deposits within the pancreatic cells of nearly all patients diagnosed with type 2 diabetes mellitus (T2DM).
Mawadda Alghrably, Giulia Bennici, Gabriela Szczupaj, Gabriela Szczupaj, Noura Alasmael, Somayah Qutub, Batoul Maatouk, Kousik Chandra, Michal Nowakowski, Abdul-Hamid Emwas, Mariusz Jaremko   +10 more
doaj   +1 more source

Metabolites from Marine Macroorganisms of the Red Sea Acting as Promoters or Inhibitors of Amylin Aggregation

Biomolecules
Amylin is part of the endocrine pancreatic system that contributes to glycemic control, regulating blood glucose levels. However, human amylin has a high tendency to aggregate, forming isolated amylin deposits that are observed in patients with type 2 ...
Mawadda Alghrably, Mohamed A. Tammam, Aikaterini Koutsaviti, Vassilios Roussis, Xabier Lopez, Giulia Bennici, Abeer Sharfalddin, Hanan Almahasheer, Carlos M. Duarte, Abdul-Hamid Emwas, Efstathia Ioannou, Mariusz Jaremko   +11 more
doaj   +1 more source

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors

Nature Communications
Obesity is a major and increasingly prevalent chronic metabolic disease with numerous comorbidities. While recent incretin-based therapies have provided pharmaceutical inroads into treatment of obesity, there remains an ongoing need for additional ...
Jianjun Cao, Matthew J. Belousoff, Rachel M. Johnson, Peter Keov, Zamara Mariam, Giuseppe Deganutti, George Christopoulos, Caroline A. Hick, Steffen Reedtz-Runge, Tine Glendorf, Borja Ballarín-González, Kirsten Raun, Charles Bayly-Jones, Denise Wootten, Patrick M. Sexton   +14 more
doaj   +1 more source

Amylin and the amylin receptors in migraine: Is there another pathway to target?

Cephalalgia
Here, we review the available evidence implicating amylin in migraine, its relationship with calcitonin gene-related peptide (CGRP) and its potential utility as a therapeutic target. The pathophysiology of migraine is currently better understood and the role of CGRP is key.
David Moreno-Ajona, Helin Gosalia, Jan Hoffmann, Peter J. Goadsby   +3 more
openaire   +2 more sources