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Amylin: From Mode of Action to Future Clinical Potential in Diabetes and Obesity. [PDF]
Volčanšek Š +4 more
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Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon. [PDF]
Loften A +3 more
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Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying protein (RAMP), thus forming AMY1-3;
Bernd Coester +2 more
exaly +3 more sources
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Headache, 2017
Amylin is a 37 amino acid peptide hormone that is closely related to calcitonin gene‐related peptide (CGRP). Amylin and CGRP share a receptor and are reported to have several similar biological actions. Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider
Debbie L HAY
exaly +3 more sources
Amylin is a 37 amino acid peptide hormone that is closely related to calcitonin gene‐related peptide (CGRP). Amylin and CGRP share a receptor and are reported to have several similar biological actions. Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider
Debbie L HAY
exaly +3 more sources
Life Sciences, 1992
Amylin is a 37 amino-acid peptide which is secreted from the pancreatic islets of Langerhans. It has major sequence homology with calcitonin gene related peptide. Amylin can precipitate out in these cells to form amyloid. Amylin is secreted by similar stimuli to those that secrete insulin.
B J, Edwards, J E, Morley
openaire +2 more sources
Amylin is a 37 amino-acid peptide which is secreted from the pancreatic islets of Langerhans. It has major sequence homology with calcitonin gene related peptide. Amylin can precipitate out in these cells to form amyloid. Amylin is secreted by similar stimuli to those that secrete insulin.
B J, Edwards, J E, Morley
openaire +2 more sources
Clinical Implications of Amylin and Amylin Deficiency
The Diabetes Educator, 1999PURPOSE this paper presents an overview of the physiology of glycemic control and the mechanisms of amylin deficiency in people with diabetes. Benefits of replacement therapy with both pramlintide and insulin are discussed. METHODS The discovery of the pancreatic p-cell hormone amylin, which is ...
D F, Kruger, P M, Gatcomb, S K, Owen
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Effects of Amylin and the Amylin Agonist Pramlintide on Glucose Metabolism
Diabetic Medicine, 1997Since the discovery of the pancreatic islet hormone amylin in 1987, its metabolic effects have been investigated in a number of studies in animals and humans. Data from some early animal studies suggested that amylin might be associated with the development of insulin resistance, but other studies found that amylin had no effect on insulin sensitivity.
O, Schmitz +4 more
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Current Opinion in Endocrinology & Diabetes, 2006
Purpose of review: The purpose of this review is to discuss the role of amylin as a glucomodulatory, neuroendocrine hormone, to highlight recent insights into its processing and sensing, to consider the pathogenic relevance of amyloid deposition to diabetogenesis, and to evaluate information relating to the therapeutic use of the amylin analogue ...
Phillips, L., Horowitz, M.
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Purpose of review: The purpose of this review is to discuss the role of amylin as a glucomodulatory, neuroendocrine hormone, to highlight recent insights into its processing and sensing, to consider the pathogenic relevance of amyloid deposition to diabetogenesis, and to evaluate information relating to the therapeutic use of the amylin analogue ...
Phillips, L., Horowitz, M.
openaire +3 more sources

