Results 141 to 150 of about 8,359 (180)
Some of the next articles are maybe not open access.
Molecular physiology of amylin
Journal of Cellular Biochemistry, 1994Amylin is a 37-amino acid peptide first isolated, purified, and characterized from the amyloid deposits in the pancrease of type 2 diabetics. It is synthesized and secreted primarily from pancreatic beta cells along with insulin. The ability of amylin to potently reduce insulin-stimulated incorporation of glucose into glycogen in skeletal muscle ...
R A, Pittner +7 more
openaire +2 more sources
Amylin and Gastrointestinal Activity
General Pharmacology: The Vascular System, 19981. Amylin is a new pancreatic islet peptide with a role in the maintenance of glucose homeostasis. 2. Amylin is predominantly present in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and in the nervous system, where amylin mRNA is also present along with specific binding sites. 3.
openaire +3 more sources
Diabetic Medicine, 1997
The presence of amyloid deposits in the pancreas was first described at the beginning of the 20th century. However, it was not until 1987 that the structure of the amylin molecule was identified. Amylin is a 37-amino-acid peptide hormone that is co-secreted with insulin by the pancreatic beta-cells in response to a nutrient stimulus. It is deficient in
B, Ludvik +4 more
openaire +2 more sources
The presence of amyloid deposits in the pancreas was first described at the beginning of the 20th century. However, it was not until 1987 that the structure of the amylin molecule was identified. Amylin is a 37-amino-acid peptide hormone that is co-secreted with insulin by the pancreatic beta-cells in response to a nutrient stimulus. It is deficient in
B, Ludvik +4 more
openaire +2 more sources
Structure and biology of amylin
Trends in Pharmacological Sciences, 1993Amylin is a recently discovered 37 amino acid peptide secreted into the bloodstream, along with insulin, from pancreatic beta-cells. It is about 50% identical to calcitonin gene-related peptides (CGRP alpha and CGRP beta) and structurally related to the calcitonins.
T J, Rink +3 more
openaire +2 more sources
Amylin and the Gastrointestinal Tract
Diabetic Medicine, 1997There is increasing evidence that alterations in the rate of gastric emptying - both acceleration and slowing - are present in patients with diabetes mellitus. A number of different factors can influence the rate of gastric emptying. For example, a large meal volume, a high-fat meal, and the presence of high glucose concentrations will all slow the ...
openaire +2 more sources
Understanding Amylin Receptors
2009Amylin is a 37 amino acid peptide that is co-secreted with insulin from pancreatic β-cells following nutrient ingestion, acting to inhibit gastric emptying, feeding and insulin-stimulated glycogen synthesis. Amylin is a member of the calcitonin (CT) family of peptides, which include CT, CT gene-related peptides (CGRP) and adrenomedullin (AM).
Just, Rasmus +4 more
openaire +2 more sources
Current opinion in investigational drugs (London, England : 2000), 2001
Pramlintide is a human amylin analog, under development by Amylin (originally in collaboration with Johnson & Johnson), as an adjunct with insulin for the potential prevention of complications of type I diabetes, and as a single agent for type II diabetes [279804], [295121], [305454].
openaire +2 more sources
Pramlintide is a human amylin analog, under development by Amylin (originally in collaboration with Johnson & Johnson), as an adjunct with insulin for the potential prevention of complications of type I diabetes, and as a single agent for type II diabetes [279804], [295121], [305454].
openaire +2 more sources
Functional study of amylin and regulation of amylin receptor
2010Amylin, a 37 amino acid peptide secreted from pancreatic beta cells upon stimulation by meal/glucose, belongs to the family of the calcitonin or calcitonin gene-related peptide (CGRP) and shares up to 50% homology with CGRP, which is a well-documented pain-related peptide.
openaire +1 more source
Science of Aging Knowledge Environment, 2004
Like a retaining wall that protects a beach house from the pounding ocean, a protein called amylin keeps bones strong by preventing their disintegration, new research shows. The results suggest a novel potential therapy against osteoporosis.
openaire +1 more source
Like a retaining wall that protects a beach house from the pounding ocean, a protein called amylin keeps bones strong by preventing their disintegration, new research shows. The results suggest a novel potential therapy against osteoporosis.
openaire +1 more source
Effects of Amylin on Eating and Adiposity
2011Amylin's best investigated function is to reduce eating via a meal size effect by promoting meal-ending satiation. This effect seems to depend on an activation of specific area postrema neurons. Brain areas that convey the neural signal to the forebrain include the nucleus of the solitary tract and the lateral parabrachial nucleus. Acute application of
openaire +2 more sources