Results 161 to 170 of about 12,396 (213)
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Current Opinion in Endocrinology & Diabetes, 2006
Purpose of review: The purpose of this review is to discuss the role of amylin as a glucomodulatory, neuroendocrine hormone, to highlight recent insights into its processing and sensing, to consider the pathogenic relevance of amyloid deposition to diabetogenesis, and to evaluate information relating to the therapeutic use of the amylin analogue ...
Phillips, L., Horowitz, M.
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Purpose of review: The purpose of this review is to discuss the role of amylin as a glucomodulatory, neuroendocrine hormone, to highlight recent insights into its processing and sensing, to consider the pathogenic relevance of amyloid deposition to diabetogenesis, and to evaluate information relating to the therapeutic use of the amylin analogue ...
Phillips, L., Horowitz, M.
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Skin capillary amylin deposition resembles brain amylin vasculopathy in rats
Journal of Stroke and Cerebrovascular Diseases, 2023Human amylin is a 37 amino-acid pancreatic peptide that forms neuro-toxic aggregates that deposit in the endothelium of brain capillaries of patients with diabetes, potentially contributing to cerebral small vessel ischemic injury. Pathogenic amylin also deposits in the capillary endothelium in other organs, including the skin.
Saurav Das +3 more
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Headache: The Journal of Head and Face Pain, 2017
Amylin is a 37 amino acid peptide hormone that is closely related to calcitonin gene‐related peptide (CGRP). Amylin and CGRP share a receptor and are reported to have several similar biological actions. Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider
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Amylin is a 37 amino acid peptide hormone that is closely related to calcitonin gene‐related peptide (CGRP). Amylin and CGRP share a receptor and are reported to have several similar biological actions. Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider
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Interictal amylin levels in chronic migraine patients: A case-control study
Cephalalgia, 2020Background Recently, amylin and its receptors were found in different structures involved in migraine pathophysiology. Here, we evaluate interictal concentrations of amylin and calcitonin gene-related peptide in peripheral blood as biomarkers for chronic
P. Irimia +7 more
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Peripheral insulin and amylin levels in Parkinson's disease.
Parkinsonism & Related Disorders, 2020BACKGROUND Type-2-diabetes (T2D) has surfaced as a potential risk factor for Parkinson's disease (PD) in some epidemiological studies. Evidence of glucose metabolism alterations in PD from molecular studies remains conflicting.
A. Sánchez-Gómez +11 more
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Amylin and Gastrointestinal Activity
General Pharmacology: The Vascular System, 19981. Amylin is a new pancreatic islet peptide with a role in the maintenance of glucose homeostasis. 2. Amylin is predominantly present in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and in the nervous system, where amylin mRNA is also present along with specific binding sites. 3.
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Molecular physiology of amylin
Journal of Cellular Biochemistry, 1994Amylin is a 37-amino acid peptide first isolated, purified, and characterized from the amyloid deposits in the pancrease of type 2 diabetics. It is synthesized and secreted primarily from pancreatic beta cells along with insulin. The ability of amylin to potently reduce insulin-stimulated incorporation of glucose into glycogen in skeletal muscle ...
R A, Pittner +7 more
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Comprehensive Physiology, 2020
This article in the Neural and Endocrine Section of Comprehensive Physiology discusses the physiology and pathophysiology of the pancreatic hormone amylin.
C. L. Foll, Thomas A. Lutz
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This article in the Neural and Endocrine Section of Comprehensive Physiology discusses the physiology and pathophysiology of the pancreatic hormone amylin.
C. L. Foll, Thomas A. Lutz
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Diabetic Medicine, 1997
The presence of amyloid deposits in the pancreas was first described at the beginning of the 20th century. However, it was not until 1987 that the structure of the amylin molecule was identified. Amylin is a 37-amino-acid peptide hormone that is co-secreted with insulin by the pancreatic beta-cells in response to a nutrient stimulus. It is deficient in
B, Ludvik +4 more
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The presence of amyloid deposits in the pancreas was first described at the beginning of the 20th century. However, it was not until 1987 that the structure of the amylin molecule was identified. Amylin is a 37-amino-acid peptide hormone that is co-secreted with insulin by the pancreatic beta-cells in response to a nutrient stimulus. It is deficient in
B, Ludvik +4 more
openaire +2 more sources
Distributed amylin receptor signaling and its influence on motivated behavior.
Physiology and Behavior, 2020The intake- and body weight-suppressive hormone amylin exerts effects on energy balance control at a variety of nuclei within the brain, including sites that have been referred to in the literature as mediating homeostatic versus hedonic aspects of ...
Katherine A. Kern +1 more
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