Results 11 to 20 of about 35,949 (206)

Safety, tolerability, immunogenicity, and efficacy of UB-311 in participants with mild Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 2a studyResearch in context

EBioMedicine, 2023
Summary: Background: Anti-amyloid vaccines may offer a convenient, affordable, and accessible means of preventing and treating Alzheimer's disease. UB-311 is an anti–amyloid-β active immunotherapeutic vaccine shown to be well-tolerated and to have a ...
Hui Jing Yu, Samuel P. Dickson, Pei-Ning Wang, Ming-Jang Chiu, Chin-Chang Huang, Chiung-Chih Chang, Hope Liu, Suzanne B. Hendrix, Jean-Cosme Dodart, Ajay Verma, Chang Yi Wang, Jeffrey Cummings   +11 more
doaj   +1 more source

Subcortical signal alteration of corticospinal tracts. A radiologic manifestation of ARIA: A case report

Radiology Case Reports, 2023
Patients with Alzheimer's disease who have been given monoclonal antibodies targeting amyloid-β (Aβ) (eg, gantenerumab, donanemab, lecanemab, and aducanumab) for scientific purposes may have a spectrum of imaging findings known as amyloid-related imaging
Houman Sotoudeh, MD, Mohammadreza Alizadeh, MD, Ramin Shahidi, MD, Parnian Shobeiri, MD, MPH, Natelson love, MD, Aparna Singhal, MD   +5 more
doaj   +1 more source

Cerebral Amyloid Angiopathy: Emerging Concepts [PDF]

Journal of Stroke, 2015
Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is classified into several types according to the amyloid protein involved.
Masahito Yamada
doaj   +1 more source

Amyloid and tau PET in cerebral amyloid angiopathy-related inflammation two case reports and literature review

Frontiers in Neurology, 2023
BackgroundCerebral amyloid angiopathy-related inflammation (CAA-ri) is a clinical syndrome characterized by MRI findings of amyloid-related imaging abnormalities-edema (ARIA-E) suggestive of autoimmune and inflammatory reaction and hemorrhagic evidence ...
Jhih-Yong Yang, Yung-Tsai Chu, Hsin-Hsi Tsai, Hsin-Hsi Tsai, Jiann-Shing Jeng   +4 more
doaj   +1 more source

Case report and risk factor analysis of amyloid-related imaging abnormalities induced by lecanemab in Alzheimer's disease [PDF]

Zhenduanxue lilun yu shijian
Amyloid-related imaging abnormalities (ARIA) represent a significant safety concern that requires attention during the treatment of Alzheimer's disease (AD) with lecanemab, and their occurrence is associated with multiple factors.
XU Chenhaoyi, LIU Jingwen, FANG Min
doaj   +1 more source

Symptomatic amyloid‐related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Amyloid‐related imaging abnormalities (ARIA) are a common, dose‐dependent effect of amyloid‐targeting antibodies, strongly associated with the apolipoprotein E (APOE) ε4 allele.
Lawren VandeVrede, Daniel M Gibbs, Mary Koestler, Renaud La Joie, Peter A. Ljubenkov, Karine Provost, David Soleimani‐Meigooni, Amelia Strom, Elena Tsoy, Gil D. Rabinovici, Adam L. Boxer   +10 more
doaj   +1 more source

In silico exploration of amyloid‐related imaging abnormalities in the gantenerumab open‐label extension trials using a semi‐mechanistic model

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction Amyloid‐related imaging abnormalities with edema/effusion (ARIA‐E) are commonly observed with anti‐amyloid therapies in Alzheimer's disease.
Roxana Aldea, Hans Peter Grimm, Ronald Gieschke, Carsten Hofmann, Dominik Lott, Szofia Bullain, Paul Delmar, Gregory Klein, Marco Lyons, Fabrizio Piazza, Roxana O. Carare, Norman A. Mazer   +11 more
doaj   +1 more source

FDG-PET versus Amyloid-PET Imaging for Diagnosis and Response Evaluation in Alzheimer’s Disease: Benefits and Pitfalls

Diagnostics, 2023
In June 2021, the US Federal Drug and Food Administration (FDA) granted accelerated approval for the antibody aducanumab and, in January 2023, also for the antibody lecanemab, based on a perceived drug-induced removal of cerebral amyloid-beta as assessed
Poul F. Høilund-Carlsen, Mona-Elisabeth Revheim, Tommaso Costa, Kasper P. Kepp, Rudolph J. Castellani, George Perry, Abass Alavi, Jorge R. Barrio   +7 more
doaj   +1 more source

Symptomatic amyloid-related imaging abnormalities after Lecanemab treatment in an APOE ε4 homozygous patient with mild cognitive impairment due to Alzheimer's disease: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To report a case of symptomatic amyloid-related imaging abnormalities (ARIA) following Lecanemab treatment in patient with mild cognitive impairment due to Alzheimer's disease (AD-MCI), so as to provide references for the clinical safe ...
CAO Wen-wei, GENG Jie-li, JI Chen-hui, SUN Wei-feng, SUN Ya-wen, WANG Gang   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source