Results 91 to 100 of about 10,843,123 (260)

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

Alzheimer’s Research & Therapy, 2018
Background Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer’s disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not been identified.
Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir, Jean Menager, Patrick Benoit, Pascal Barneoud, Véronique Taupin, Philippe Bertrand, Philippe Dugay, Béatrice Cameron, Yi Shi, Souad Naimi, Marc Duchesne, Marie Gagnaire, Tim Weeden, Tara Travaline, David Reczek, Leonard Khiroug, Mohamed Slaoui, Pascale Brunel, Hidehiro Fukuyama, Jeffrey Ravetch, Thierry Canton, Caroline Cohen   +24 more
doaj   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Amyloid-Related Imaging Abnormalities in Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer’s Disease: Expert Recommendation for Standard MRI Protocol

Journal of the Korean Society of Radiology
The introduction of anti-amyloid therapies for Alzheimer’s disease (AD), such as lecanemab (Lequembi ®), which was recently approved in Korea, necessitates careful monitoring for amyloid-related imaging abnormalities (ARIA) using brain MRI. To optimize
Jimin Kim, Eunhee Kim, Mina Park, Yun Jung Bae, Chong Hyun Suh, Sung-Hye You, Younghee Yim, Ho-Joon Lee, Jin Wook Choi, Se Won Oh, Won-Jin Moon   +10 more
doaj   +1 more source

Alzheimer's Disease Beyond Amyloid: Lessons From Atherosclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Marcello Ciaccio, Luisa Agnello
wiley   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease. [PDF]

, 2012
In Alzheimer’s disease (AD), persistent microglial activation as sign of chronic neuroinflammation contributes to disease progression. Our study aimed to in vivo visualize and quantify microglial activation in 13- to 15-month-old AD mice using [11C]-(R ...
Viel, Thomas, Neumaier, Bernd, Höhn, Mathias, Rapic, Sara, Van der Linden, Annemie, Höhn, M., van der Linden, A., Jacobs, Andreas H, Kummer, Markus P., Jacobs, Andreas H., Hoehn, Mathias, Vollmar, Stefan, Heneka, M., Rapic, S., Backes, H., Jacobs, A., HENEKA, Michael, Vollmar, S., Neumaier, B., Kummer, M., Monfared, P., Backes, Heiko, Kummer, Markus P, Viel, T., Heneka, Michael T., Heneka, Michael T, Monfared, Parisa   +26 more
core   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1 [PDF]

, 2011
Peer ...
Mingarelli Marco, Emanuele Porcu, Ryan Duncan, Platt, Bettina, Riedel, Gernot, David Koss, Utan Aneli, Benjamin Drever, Scrocchi Louise, Scrocchi, Louise, Andrea Plano, Andy Welch, Gernot Riedel, Utan, Aneli, Koss David, Porcu Emanuele, Mingarelli, Marco, Marco Mingarelli, Plano, Andrea, Merrick Georgina, Welch, Andy, Hong Wan, Plano Andrea, Sandra Stoppelkamp, Drever, Benjamin, Wan Hong, Wan, Hong, Valeria Melis, Duncan Ryan, Georgina Merrick, Welch Andy, Koss, David, Jyoti, Amar, Porcu, Emanuele, Aneli Utan, Louise Scrocchi, Stoppelkamp, Sandra, Riedel Gernot, Bettina Platt, Amar Jyoti, Platt Bettina, Stoppelkamp Sandra, Merrick, Georgina, Ryan, Duncan, Melis, Valeria, Melis Valeria, Drever Benjamin, Jyoti Amar   +47 more
core   +2 more sources

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source