Results 201 to 210 of about 11,332,305 (264)

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single‐centre prospective pilot study

Internal Medicine Journal, EarlyView.
Abstract Background Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (AL) amyloidosis, or congestive hepatopathy, more typical in transthyretin (ATTR)
M Tang, N Vootukuru, J Tjahyadi, D Clayton Chubb, H Jina, SB Ting, S Bloom, R Sawhney, S Gibbs, O. Niewiadomski   +9 more
wiley   +1 more source

Incidence of amyloid-related imaging abnormalities and health resource utilization in patients with Alzheimer disease receiving monoclonal antibody treatments: A real-world evidence study. [PDF]

J Manag Care Spec Pharm
Dangpiaei S, Kamal KM, Shoair OA, Al-Mamun MA.   +3 more
europepmc   +1 more source

Feasibility, Safety, and Efficacy of Pulsed Field Ablation for Ventricular Arrhythmias: Insights From a Large Health System Registry in the United States

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pulsed field ablation (PFA) is an emerging non‐thermal ablation modality with proven safety in atrial arrhythmia ablation. However, data on its performance for ventricular arrhythmias (VA) remain limited. Objective To evaluate the feasibility, safety, and efficacy of PFA for complex VA in a multicenter real‐world US registry ...
Narut Prasitlumkum, Juan F. Rodriguez‐Riascos, Hema Vemulapalli, Aakash Somappa, Camilo A. Estrada‐Vargas, Olubadewa A. Fatunde, Carlos A. Rojas, Poojan Prajapati, Keerthika Vijayakumar, Suraj Kapa, Duy Nguyen, Samuel Asirvatham, Malini Madhavan, Christopher McLeod, Hicham Z. El Masry, Abhishek J. Deshmukh, Danesh K. Kella, Ammar M. Killu, Siva K. Mulpuru, Mayank Sardana, Luis R. Scott, Alan M. Sugrue, Komandoor Srivathsan   +22 more
wiley   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Amyloid-related Imaging Abnormalities (ARIA) in the Context of Alzheimer's Disease and Amyloid-targeting Therapies: An Introduction for Advanced Practice Providers. [PDF]

Drugs Aging
Schreiber CP, Kovacik A, Bishop J, Helman J.   +3 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Neuropathological changes and amyloid-related imaging abnormalities in Alzheimer's disease treated with aducanumab versus untreated: a retrospective case-control study. [PDF]

Lancet Neurol
Boon BDC, Piura YD, Moloney CM, Chalk JL, Lincoln SJ, Rutledge MH, Rothberg DM, Kouri N, Hinkle KM, Roemer SF, Johnson DR, Burkett BJ, Lowe VJ, Petersen RC, Dickson DW, Reichard RR, Nguyen AT, Graff-Radford J, Knopman DS, Graff-Radford NR, Murray ME.   +20 more
europepmc   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Neurite Imaging Reveals Widespread Alterations in Grey Matter Neurite Morphology in Obstructive Sleep Apnoea

Journal of Sleep Research, EarlyView.
ABSTRACT Obstructive sleep apnoea (OSA) is a common chronic multisystem disorder, and cortical structural alterations have been detected via conventional neuroimaging techniques. Recent advances in diffusion‐weighted imaging have yielded novel techniques for investigating neural microstructure, which may potentially offer supplementary insights into ...
Liping Qi, Qiu Chu, Ya‐Jie Liu, Rong‐Hua Li, Ling Wen, Yong‐Zhong Lin   +5 more
wiley   +1 more source