Results 101 to 110 of about 11,328,563 (174)

APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy

Frontiers in Dementia
APOE-ε4 allele[s] is a risk factor for Alzheimer's disease (AD) and Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy, and is also associated with cerebrovascular risk factors such as hyperlipidemia or atherosclerosis.
Kenichiro Sato, Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata, Takeshi Iwatsubo, Takeshi Iwatsubo   +7 more
doaj   +1 more source

S4‐02‐04: Amyloid‐Related Imaging Abnormalities (ARIA) [PDF]

Alzheimer's & Dementia, 2012
openaire   +1 more source

Anti-amyloid-β monoclonal antibody for Alzheimer's disease: value, clinical practice and challenges

Chinese Journal of Contemporary Neurology and Neurosurgery
The success of anti-amyloid-β (Aβ) monoclonal antibody has marked the beginning of the disease-modifying therapy (DMT) era for Alzheimer's disease (AD). As these agents are increasingly adopted in clinical practice, the focus of management has gradually ...
WANG Gang, GENG Jie-li
doaj   +1 more source

Efficacy and Safety of Recently Approved Anti-Amyloid Monoclonal Antibodies in Early Alzheimer's Disease: A Meta-Analysis

International Journal of Medical Students
Background Alzheimer's disease (AD) is the leading cause of dementia worldwide and affects over 55 million people.  Lecanemab and donanemab are anti-amyloid monoclonal antibodies that flag the abnormal amyloid-beta plaques for removal by the ...
Hassan Khalid, Mohammed Murtada
doaj  

TNF inhibition differentially impacts regional Abeta immunotherapy efficacy in the humanized hAbSAA mouse model

Alzheimer’s Research & Therapy
Background The FDA approval of amyloid beta (Aβ) targeting immunotherapies offered the first opportunity to clinically modify Alzheimer’s disease progression and give patients back precious months in the course of disease progression.
Katelynn E. Krick, Jessica L. Chalk, Joshua T. Lykins, Hsin-Pei Wang, Chloe A. Ferguson, Syed Salman Shahid, Erica M. Weekman, Donna M. Wilcock   +7 more
doaj   +1 more source

Severe cerebral amyloid angiopathy related inflammation (CAA-ri) associated with vaccination: Case report and literature review

Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rapid but reversible autoimmune encephalopathy where spontaneous autoantibody reaction against amyloid beta deposited in cerebral blood vessels produces characteristic neuroinflammatory ...
Lau, Kui Kai, Tang, Michael, Kim, Jane, Chan, Koon Ho   +3 more
core   +1 more source

Additional file 1 of Amyloid-related imaging abnormalities (ARIA) in Alzheimer’s disease: from pathophysiology to individualized risk assessment

Supplementary Material 1.
Merkel, Jonathan, Perneczky, Robert, Jessen, Frank, Frölich, Lutz, Jansen, Olav, Peters, Sönke, Berg, Daniela, Schulz, Jörg B., Bartsch, Thorsten   +8 more
openaire   +1 more source

Investigating amyloid-related imaging abnormalities (ARIA) using neurosurgical biopsies of CAA-related inflammation (CAA-ri): what constitutes a neuropathological diagnosis of CAA-ri?

Background: spontaneous cerebral amyloid angiopathy–related inflammation (CAA-ri) has been proposed as a model for the amyloid-related imaging abnormalities (ARIA) seen following amyloid-beta (Aβ) immunotherapy.
Walker, Mark, Boche, Delphine, Nicoll, James, Katharkamar, Athushan, Fabian, Mark, Kurian, Kathreena M., Highley, J. Robin, Jaunmuktane, Zane, Norton, Emma, Kurian, Kathreena, Cro, Bethany   +10 more
core   +1 more source

Amyloid-Related Imaging Abnormalities in Clinical Trials of Gantenerumab in Early Alzheimer Disease [PDF]

IMPORTANCE: Data from 2 phase 3 studies of gantenerumab, GRADUATE I/II, and their open-label extensions represent a resource to further characterize amyloid-related imaging abnormalities (ARIA), including long-term sequelae.
Voyle, Nicola, Bullain, Szofia, Doody, Rachelle, Wojtowicz, Jakub, Bittner, Tobias, Smith, Janice, Boada, Mercè, Klein, Gregory, Schneider, Andres, Aldea, Roxana, Lane, Christopher A, Lyons, Marco, Salloway, Stephen, Rossomanno, Simona, Barkhof, Frederik, Mazzo, Francesca, Grundman, Michael   +16 more
core   +1 more source

Artificial Intelligence-Assisted Detection of Amyloid-Related Imaging Abnormalities: Promise and Pitfalls. [PDF]

AJNR Am J Neuroradiol
Petrella JR, Liu AJ, Wang LA, Doraiswamy PM.   +3 more
europepmc   +1 more source