Results 131 to 140 of about 466,481 (267)

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

The capacity for Alzheimer's disease confirmatory testing in the United States: The current situation and simulations for future increase. [PDF]

J Alzheimers Dis
Roth S, Yan J, Patru MM, Mattke S, Gustavsson A, Ortsater G.   +5 more
europepmc   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Multimodal Diagnosis of Cardiac Amyloidosis: Integrating Imaging, Histochemistry, and Proteomics of Precise Typing. [PDF]

Int J Mol Sci
Kancerek J, Zniszczoł Ł, Lewandowski P, Wojnicz R.   +3 more
europepmc   +1 more source

Efficacy of Contractility Modulation Therapy in Patients with Transthyretin Amyloid Cardiomyopathy, Mildly Reduced to Reduced EF and NYHA III and IV: A Multicentric, Prospective Pilot Study for AMY-CCM Registry

Procolo Marchese, Francesca Gennaro, Giovanni Mazzotta, Pierfrancesco Grossi, L Cocchiara, Stefano Guarracini, L Mazzocchetti, Matteo Ziacchi, Mauro Biffi, R Magnano, Massimo Di Marco, Matteo Ruzzolini, Antonio Bisignani, Matteo Bianco, Paolo Garrone, Walter Grosso Marra, Margherita Cannillo, Carlo Lavalle, Daniele Masarone, Cristina Chimenti   +19 more
openalex   +1 more source

Charakterisierung von Antikörpern gegen das Pyroglutamat-3-Amyloid-beta Peptid (AβpE3-Peptid) als Voraussetzung für eine potentielle Anwendung in der Alzheimer Immuntherapie

, 2017
Anke Piechotta
openalex   +2 more sources

Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein [PDF]

, 2010
Can Zhang, Andrew Browne, Daniel D. Child, Jason DiVito, Jesse A. Stevenson, Rudolph E. Tanzi   +5 more
openalex   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Motor, not cognitive, performance relates to amyloid status in normal older adults. [PDF]

Alzheimers Dement (Amst)
Cook Maher A, Rose S, DuBois KN, Kanaan NM, Koeppe R, Bross J, Flynn E, Murphey YL, Persad CC, Giordani B.   +9 more
europepmc   +1 more source

Suppressed Accumulation of Cerebral Amyloid β Peptides in Aged Transgenic Alzheimer’s Disease Mice by Transplantation with Wild-Type or Prostaglandin E2 Receptor Subtype 2-Null Bone Marrow [PDF]

, 2010
C. Dirk Keene, Rubens Chang, Américo H. López-Yglesias, Bryan Richard Shalloway, Izabella Sokal, Xianwu Li, Patrick Reed, Lisa Keene, Kathleen S. Montine, Richard Breyer, Jason K. Rockhill, Thomas J. Montine   +11 more
openalex   +1 more source