Advanced Science, EarlyView.This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
wiley +1 more source
PAK1 inhibitor NVS‐PAK1‐1 inhibits degeneration of synaptic spines in cultured neurons exposed to amyloid or tau and in 5XFAD mice following oral administration [PDF]
Frank M. Longo
openalex +1 more source
MEGF10 functions as a receptor for the uptake of amyloid‐β [PDF]
, 2010 Thoudam Debraj Singh +6 more
openalex +1 more source
CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, EarlyView.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
Amyloid Precursor Proteins Interact with the Heterotrimeric G Protein Go in the Control of Neuronal Migration [PDF]
, 2013 Jenna M. Ramaker +2 more
openalex +1 more source
Nanozymes Integrated Biochips Toward Smart Detection System
Advanced Science, EarlyView.This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen +10 more
wiley +1 more source
A regional framework for the detection and management of ARIA with anti-amyloid therapies in early Alzheimer's disease in Asia. [PDF]
J Prev Alzheimers DisMoon SY +8 more
europepmc +1 more source
Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada [PDF]
, 2016 Robert Laforce +5 more
openalex +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Imaging and fluid biomarkers for prognostic stratification in cerebral amyloid angiopathy. [PDF]
J NeurolWang D, Lv S, Wei Y, Zhao X.
europepmc +1 more source