Results 241 to 250 of about 514,761 (295)

Self‐Assembly, Rearrangement, and Disassembly of {Cr6} Horseshoe Oligomers

Angewandte Chemie, EarlyView.
Using a combination of ion mobility mass spectrometry (IM‐MS), tandem mass spectrometry (MS2), and low‐temperature scanning tunneling microscopy (STM), we elucidate the self‐assembly, rearrangement, and disassembly processes of polymetallic {Cr6}x (x = 1 – 5) horseshoe oligomers.
Niklas Geue, Dhaneesh Kumar, Jimin Ham, Shengpeng Huang, Grigore A. Timco, Neil A. Burton, Richard E. P. Winpenny, Kelvin Anggara, Perdita E. Barran   +8 more
wiley   +2 more sources

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, EarlyView.
Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease.
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation

Angewandte Chemie, EarlyView.
Al3+ competes with Fe3+ for transferrin (Tf) binding and enters cells via transferrin receptor (TfR)‐mediated endocytosis, disrupting cellular iron homeostasis. Intracellular vesicle impact electrochemical cytometry (IVIEC) and single‐cell amperometry (SCA), which record the oxidation of dopamine, reveal increased neurotransmitter storage and ...
Shi‐Hua Chen, Chaoyi Gu, Xing‐Jiu Huang, Andrew G. Ewing   +3 more
wiley   +2 more sources

Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease

, 2014
Michelle M. Mielke, Norman J. Haughey, Veera Venkata Ratnam Bandaru, Henrik Zetterberg, Kaj Blennow, Ulf Andréasson, Sterling C. Johnson, Carey E. Gleason, Hanna M. Blazel, Luigi Puglielli, Mark A. Sager, Sanjay Asthana, Cynthia M. Carlsson   +12 more
openalex   +1 more source

Three‐Segment Protein Labeling Using a Highly Efficient and Cysteine‐Less Split Intein Identified with Computational Prediction of Aggregation Properties

Angewandte Chemie, EarlyView.
Tandem protein trans‐splicing (PTS) assembles a protein from three segments. Expanding this technology to individually treat cysteines in each segment, for example, for chemical labeling using thiol bioconjugation, the authors identify a second, highly efficient cysteine‐less split intein.
Christoph Humberg, Jonas Kröger, Shmuel Pietrokovski, Henning D. Mootz   +3 more
wiley   +2 more sources

N‐Amino Peptide–Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

Advanced NanoBiomed Research, EarlyView.
A neuron‐targeting drug delivery system is developed by incorporating the tau‐specific N‐amino peptide, mxyl‐NAP2, with graphene quantum dots (GQDs) and encapsulating the complex into small extracellular vesicles functionalized with a neuron‐targeting ligand.
Runyao Zhu, Gaeun Kim, Benjamin H. Rajewski, Isaac J. Angera, Juan R. Del Valle, Yichun Wang   +5 more
wiley   +1 more source

Cerebral amyloid angiopathy impacts neurofibrillary tangle burden and cognition

Dana Godrich, Jeremy Pasteris, Eden R. Martin, Tatjana Rundek, Gerard D. Schellenberg, Tatiana Foroud, Jeffery M. Vance, Margaret A Pericak‐Vance, Michael L. Cuccaro, William K. Scott, Walter A. Kukull, Thomas J. Montine, Gary W. Beecham   +12 more
openalex   +1 more source

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

Science, 2017
L. Gremer, Daniel Schölzel, Carla Schenk, Elke Reinartz, J. Labahn, R. Ravelli, Markus Tusche, C. López-Iglesias, W. Hoyer, H. Heise, D. Willbold, G. Schröder   +11 more
semanticscholar   +1 more source

Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper

, 2016
Shin Jung C. Lee, Tae Su Choi, Jong‐Wha Lee, Hyuck Jin Lee, Dong‐Gi Mun, Satoko Akashi, Sang‐Won Lee, Mi Hee Lim, Hugh I. Kim   +8 more
openalex   +2 more sources

Protective effects of Dendrobium nobile Lindl. alkaloids on amyloid beta (25–35)-induced neuronal injury

, 2017
Jing-Shan Shi, Wei Zhang, Qin Wu, Yan-Liu Lu, Qihai Gong, Feng Zhang   +5 more
openalex   +1 more source