Results 81 to 90 of about 466,481 (267)

Thermal Stability Of Oriented Aß25-35 Amyloid Fibril Nanoarray [PDF]

, 2009
Matyas Kolsofszki, Árpád Karsai, Miklós Kellermayer   +2 more
openalex   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

P1–104: Assessing the effects of memantine in APP/PS1 transgenic mice by behavioral studies and ex vivo imaging of amyloid plaques using gadolinium labeled amyloid β peptides and micromri [PDF]

, 2006
Thomas Wısnıewskı, Henrieta Scholtzova, Youssef Zaim Wadghiri, Einar M. Sigurdsson, Moustafa Douadi, Yongsheng Li, David Quartermain, Pradeep Banerjee   +7 more
openalex   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Monitoring patients and asymptomatic carriers with hereditary transthyretin amyloidosis: regional protocol of Emilia-Romagna ATTR working group

Frontiers in Neurology
Transthyretin amyloidosis (ATTR) is a rare disease caused by the extracellular accumulation of misfolded transthyretin (TTR) amyloid fibrils. ATTR can be either hereditary (ATTRv) or acquired (wtATTR).
Pietro Guaraldi, Isabella Allegri, Alessandra Ariatti, Tommaso Baldini, Andrea Barbieri, Federico Barocelli, Michela Bartolotti, Elena Biagini, Elena Biagini, Francesca Bianchi, Annamaria Borghi, Claudia Borghi, Giuseppe Boriani, Ilaria Cani, Samuela Carigi, Luca Codeluppi, Marco Currò Dossi, Francesca Dalpozzo, Roberto D’Angelo, Riccardo De Gennaro, Francesco Di Spigno, Elisa Gardini, Gianluca Lanati, Chiara Leuzzi, Francesca Marzo, Marco Masullo, Gaia Mazzanti, Elisa Merli, Agnese Milandri, Dennis Monari, Enrica Perugini, Alberto Ponziani, Alberto Ponziani, Emanuela Postiglione, Marta Rasia, Rita Rinaldi, Davide Scancarello, Kevin Serafini, Matteo Serenelli, Maurizio Sguazzotti, Ernesto Siena, Anna Maria Simone, Chiara Terracciano, Chiara Valenti, Giovanni Vitale, Maria Vitiello, Simone Longhi   +46 more
doaj   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

The Cognitive Changes Among Patients over 65 Years of Age in a Rural Area—The Preliminary Report of Protective and Predisposing Factors

Neurology International
Background: Aβ1-42 and APOE concentrations, as well as Aβ42/40 ratio, may be considered as a link between hypertension (HTN) or diabetes mellitus (DM), brain amyloidosis, and dementia.
Radoslaw Zachara, Daria Gendosz de Carrillo, Adam Wlaszczuk, Agnieszka Gorzkowska, Wiktoria Mazur, Halina Jedrzejowska-Szypulka   +5 more
doaj   +1 more source

Plasma amyloid-β40 in relation to subclinical atherosclerosis and cardiovascular disease: A population-based study [PDF]

, 2022
Frank J. Wolters, Saima Hilal, Maarten J.G. Leening, Maryam Kavousi, Mohsen Ghanbari, Oscar H. Franco, Albert Hofman, Peter J. Koudstaal, Meike W. Vernooij, M. Kamran Ikram, Daniël Bos, M. Arfan Ikram   +11 more
openalex   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source