Results 81 to 90 of about 516,976 (376)

Transmissible amyloid [PDF]

Journal of Internal Medicine, 2016
AbstractThere are around 30 human diseases associated with protein misfolding and amyloid formation, each one caused by a certain protein or peptide. Many of these diseases are lethal and together they pose an enormous burden to society. The prion protein has attracted particular interest as being shown to be the pathogenic agent in transmissible ...
Jan Johansson, Jan Johansson, Anna Rising, Anna Rising, Kristaps Jaudzems, Per Westermark, Lars O. Tjernberg   +6 more
openaire   +3 more sources

Differentiation of Bacillus cereus Species Based on Detected Unamplified Bacterial 16S rRNA by DNA Nanomachine

Bio-Protocol
Traditional approaches for the detection and differentiation of Bacillus cereus group species often face challenges due to the complexity of genetic discrimination between species.
Muhannad Ateiah, Erik Gandalipov, Aleksandr Rubel, Maria Rubel   +3 more
doaj   +1 more source

Respiratory ß-2-Microglobulin exerts pH dependent antimicrobial activity

Virulence, 2020
The respiratory tract is a major entry site for microbial pathogens. To combat bacterial infections, the immune system has various defense mechanisms at its disposal, including antimicrobial peptides (AMPs).
Armin Holch, Richard Bauer, Lia-Raluca Olari, Armando A. Rodriguez, Ludger Ständker, Nico Preising, Merve Karacan, Sebastian Wiese, Paul Walther, Yasser B. Ruiz-Blanco, Elsa Sanchez-Garcia, Christian Schumann, Jan Münch, Barbara Spellerberg   +13 more
doaj   +1 more source

Anticholinergic Drugs Interact With Neuroprotective Chaperone L-PGDS and Modulate Cytotoxicity of Aβ Amyloids

Frontiers in Pharmacology, 2020
Anticholinergic drugs can be used as a treatment for many diseases. However, anticholinergic drugs are also known for their cognition-related side effects. Recently, there has been an increasing number of reports indicating a positive association between
Kimberly Jia Yi Low, Margaret Phillips, Konstantin Pervushin   +2 more
doaj   +1 more source

Identification of Causal Relationship between Amyloid-beta Accumulation and Alzheimer's Disease Progression via Counterfactual Inference [PDF]

arXiv, 2023
Alzheimer's disease (AD) is a neurodegenerative disorder that is beginning with amyloidosis, followed by neuronal loss and deterioration in structure, function, and cognition. The accumulation of amyloid-beta in the brain, measured through 18F-florbetapir (AV45) positron emission tomography (PET) imaging, has been widely used for early diagnosis of AD.
arxiv  

Select polyphenols protect mitochondria against amyloid aggregates in Alzheimer and Parkinson diseases [PDF]

, 2014
Alzheimer and Parkinson diseases are age-related neurodegenerative disorders in which formation of amyloid aggregates by amyloid-beta (Abeta) and α-synuclein (αS) proteins, respectively, are recognised critical events that occur early in the disease ...
Caruana, Mario, Vassallo, Neville
core   +1 more source

Modeling amyloids in bacteria [PDF]

Microbial Cell Factories, 2012
An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness ...
Villar Piqué, Anna, Ventura, Salvador
openaire   +7 more sources

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Surgical treatment of a rare case of bilateral ptosis due to localized ocular amyloidosis [PDF]

, 2016
We describe a rare case of a 31-year old woman with bilateral ptosis due to localized amyloidosis. She referred a nine-year history of ptosis and surgical treatment with frontalis suspension three years previously.
ABDOLRAHIMZADEH, SOLMAZ, MAZZOCCHI, Marco, RECUPERO, Santi Maria, SCUDERI, GIANLUCA, TROCCOLA, Antonietta   +4 more
core   +1 more source

Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez, Linn Oftedal, Johannes Lange, Diego Alejandro Tovar‐Rios, Ole‐Bjørn Tysnes, Claire Paquet, Marta Marquié, Mercè Boada, Daniel Alcolea, Konrad Rejdak, Ewa Papuc, Jakub Hort, Cristian Falup‐Pecurariu, Dag Aarsland, Guido Alves, Jodi Maple‐Grødem   +15 more
wiley   +1 more source