Results 211 to 220 of about 45,801 (303)
VIEW, EarlyView.This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu +10 more
wiley +1 more source
Biophysical Studies of the Interaction between Optimized Peptides and Amyloid-Beta Elucidate a Completely Novel Binding Mode [PDF]
, 2017 Tamar Ziehm +3 more
openalex +1 more source
Molecular analysis of 3D domain swapping in the acylphosphatase from Escherichia coli
Acta Crystallographica Section D, EarlyView.Structures of the monomer and intertwined dimer of the acylphosphatase from E. coli shed light on the molecular basis of its 3D domain swapping.Three‐dimensional domain swapping is a mechanism by which proteins form oligomers. At present, the molecular basis that dictates whether some proteins fold in their monomeric form or as intertwined oligomers is
Sergio Martínez-Rodríguez +4 more
wiley +1 more source
Antibody-Based Magnetic Nanoparticle Immunoassay for Quantification of Salivary Beta-Amyloid Peptides [PDF]
, 2014 Chang-Beom Kim, Ki‐Bong Song
openalex +1 more source
Andrology, EarlyView.Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre +5 more
wiley +1 more source
The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific [PDF]
, 2016 Ioannis Dafnis +6 more
openalex +1 more source
Brain Pathology, EarlyView.The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown +7 more
wiley +1 more source
P2–409: Neuroprotection by the synthetic enantiomers of the neurosteroids PREGS and DHEAS against beta‐amyloid 25–35 peptide–induced toxicity [PDF]
, 2013 Tangui Maurice +7 more
openalex +1 more source
Brain Pathology, EarlyView.Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari +10 more
wiley +1 more source