Results 221 to 230 of about 117,808 (299)

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Evaluation of Enzyme Inhibition and Kinetic Profiles of Origanum Essential Oils on Metabolic and Central Nervous System Targets

Natural Sciences, Volume 6, Issue 3, July 2026.
The essential oils of three Origanum species were chemically characterized and evaluated for their antioxidant and enzyme inhibitory activities. The different compositions confer selective bioactivities: O. vulgare exhibits good antioxidant and α‐glucosidase inhibitory activity, O. majorana shows promising tyrosinase inhibition, and O.
Giuseppe Amato, Lucia Caputo, Laura De Martino, Daniela Grulova, Barbara Borczak, Joanna Kapusta‐Duch, Vincenzo De Feo   +6 more
wiley   +1 more source

Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides. [PDF]

Front Aging Neurosci, 2017
Yang S, Pascual-Guiral S, Ponce R, Giménez-Llort L, Baltrons MA, Arancio O, Palacio JR, Clos VM, Yuste VJ, Bayascas JR.   +9 more
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Nanoshell Fabrication Techniques for Probiotic Encapsulation: A Comprehensive Review

eFood, Volume 7, Issue 3, June 2026.
ABSTRACT Probiotics, beneficial microorganisms, confer numerous health benefits when administered. However, their efficacy is hindered by harsh gut conditions, including acidity, bile acids, and enzymatic degradation. To overcome these challenges, encapsulation and nanoshell technology have emerged as a pivotal strategy to enhance probiotic stability ...
Tuba Mustafa, Muhammad Afzaal, Farhan Saeed, Amna Shahbaz, Zainab Hira, Ayesha Adil, Tayyaba Sohail, Faiyaz Ahmed, Maryam Amanullah, Hina Sarwar, Noor Akram, Saad Mansoor, Gebremichael Gebremedhin Hailu   +12 more
wiley   +1 more source

The interplay between the pyramidalization of carbonyl carbons and the n → π* interactions in biomolecules

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The structural preferences of biomolecules arise from a delicate balance of different forces whose identification and quantification are challenging. Studies conducted over the last two decades have shown that the n → π* interaction formed between consecutive carbonyl groups plays a crucial role in stabilizing biomolecules, which exhibit a ...
Luigi Vitagliano, Luciana Esposito
wiley   +1 more source

Amyloid Alpha: The Neglected Cousin of Amyloid Beta. [PDF]

Chembiochem
Raskatov JA.
europepmc   +1 more source

Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Kaempferol has been shown to be beneficial in the treatment of Alzheimer's disease (AD) in animal models. However, the action mechanism remains unclear. AKR1B1 has been identified as a target of kaempferol, initially suggested by the Therapeutic Target Database, DrugBank, and PubChem, and subsequently confirmed through experimental validation.
Le Li, Manying Yang, Jiale Tao, Yonghong Zhao, Na Zhao, Shiguo Sun   +5 more
wiley   +1 more source

Fibril Synthesis From Food Processing By‐Products and Strategies for Structure–Function Stabilization for Food Applications

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Protein fibrils can be synthesized from both conventional and by‐product protein sources, each having distinct advantages. Stabilization through polysaccharides and polyphenols can enhance fibril functional properties, such as gelling, foaming, and emulsification, thus furthering their application in food and non‐food materials.
Sanjana Sawant, Audrey L. Girard
wiley   +1 more source