Results 231 to 240 of about 117,808 (299)

Proxies of Cognitive Reserve and Association With Cognitive Decline and Dementia in Aging Adults With Down Syndrome

Journal of Policy and Practice in Intellectual Disabilities, Volume 23, Issue 2, June 2026.
ABSTRACT Unquestionably, with the increase in life expectancy, dementia has become a significant health issue in Down syndrome (DS). However, in at least a subset of these individuals, cognitive aging can be considered normal, with absence of dementia symptoms even in the presence of Alzheimer's neuropathology.
Livea Carla F. G. Sant'Ana, Aline S. G. G. Conceição, Luciana M. Fonseca, Orestes V. Forlenza   +3 more
wiley   +1 more source

Stress-induced alteration of small extracellular vesicles drives amyloid-beta sequestration and exacerbates Alzheimer's disease pathogenesis. [PDF]

Alzheimers Res Ther
Zehra S, Rai S, Rani K, Choudhury SD, Rai H, Bhowmik S, Mohan N, Gupta A, Chatterjee P, Reddy TJ, Rani N, Modi GP, Nikolajeff F, Kumar S.   +13 more
europepmc   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Non-Coding DNA-Derived Mimotopes of Aβ₄₂ as Novel Candidates for Alzheimer's Peptide Vaccine Design. [PDF]

Int J Med Sci
Raj N, R SP, Ammar RB, Rajendran P, Chellappan BV.   +4 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

K16F/E22F Mutation Promotes Oligomerization and Alters β-Sheet Topology of Aβ16-22 Peptides: Insights from Molecular Dynamics Simulations. [PDF]

ACS Chem Neurosci
Man VH, He X, Niu T, Cai L, Han F, Nguyen P, Wang J.   +6 more
europepmc   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

The amyloid-beta wave hypothesis of Alzheimer's disease. [PDF]

Front Cell Infect Microbiol
Miller SJ, Logan R, Zhang C, Hafler BP.
europepmc   +1 more source

Amyloid-ß Acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2 [PDF]

Alifragis, P, Austen, BM, Beesley, PW, Empson, RM, Russell, CL, Semerdjieva, S   +5 more
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