Results 1 to 10 of about 263,171 (259)
Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC [PDF]
Advanced Science, 2020 The gut–brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (Aβ), the pathogenic peptide associated with ...
Ibrahim Javed +10 more
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Amyloid Alpha: The Neglected Cousin of Amyloid Beta. [PDF]
ChembiochemFor decades, amyloid β (Aβ) has been the principal therapeutic target for therapies of Alzheimer's disease (AD). An alternative processing product, known as P3, may form if the amyloid precursor protein is cleaved by α‐secretase instead of β‐secretase.
Raskatov JA.
europepmc +3 more sources
Frontiers in Aging Neuroscience, 2020 Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Felix Dinkel +7 more
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The amyloid-beta wave hypothesis of Alzheimer’s disease [PDF]
Frontiers in Cellular and Infection MicrobiologyAlzheimer’s disease (AD) is a complex and multifactorial disorder that affects all races and genders. Genetic traits influenced by lifestyle and environment lead to a tremendous amount of heterogeneity in Alzheimer’s disease onset and severity ...
Sean J. Miller +6 more
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Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
Neural Regeneration Research, 2022 Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau ...
Alejandro R Roda +4 more
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Journal of Neuroinflammation, 2021 Background Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer’s disease models; however, evidence of its occurrence in humans remains scarce.
Lisi Flores-Aguilar +6 more
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Amyloid‐Beta Interaction with Mitochondria [PDF]
International Journal of Alzheimer’s Disease, 2011 Mitochondrial dysfunction is a hallmark of amyloid‐beta(Aβ)‐induced neuronal toxicity in Alzheimer′s disease (AD). The recent emphasis on the intracellular biology of Aβ and its precursor protein (AβPP) has led researchers to consider the possibility that mitochondria‐associated and/or intramitochondrial Aβ may directly cause neurotoxicity.
Pagani, Lucia, Eckert, Anne
openaire +4 more sources
Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. [PDF]
PLoS ONE, 2010 beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population.
William J Netzer +7 more
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Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
Molecular Brain, 2022 The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms.
Alexander S. Mihaescu +6 more
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Small-angle X-ray scattering characterization of a $$\beta $$ β -amyloid model in phantoms
BMC Research Notes, 2020 Objective We present a method to prepare an amyloid model at scalable quantities for phantom studies to evaluate small-angle x-ray scattering systems for amyloid detection. Two amyloid models were made from a plasma protein with and without heating. Both
Sophya Breedlove +3 more
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