Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]
, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory +5 more
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Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
Cells, 2019 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and ...
P. Reddy, D. Oliver
semanticscholar +1 more source
Malang Neurology Journal, 2017 Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversible neuronal cell loss, which can interfere with social and occupational functioning.
M. Rasjad Indra +2 more
doaj +1 more source
Fibril fragmentation in amyloid assembly and cytotoxicity: When size matters [PDF]
, 2010 Amyloid assemblies are associated with several debilitating human disorders. Understanding the intra- and extracellular assembly of normally soluble proteins and peptides into amyloid aggregates and how they disrupt normal cellular functions is therefore
Xue, Wei-Feng +3 more
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Frontiers in Aging Neuroscience, 2020 Despite the extensive use of hormonal methods as either contraception or menopausal hormone therapy (HT), there is very little known about the potential effects of these compounds on the cellular processes of the brain.
Keyana N. Porter +6 more
doaj +1 more source
Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico. [PDF]
PLoS ONE, 2016 Amyloid-beta peptides have long been implicated in the pathology of Alzheimer's disease. Bexarotene, a drug approved by the U.S. Food and Drug Administration for treating a class of non-Hodgkin's lymphoma, has been reported to facilitate the removal of ...
Joseph Rosenthal +2 more
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Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]
, 2013 Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A, +9 more
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Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin [PDF]
, 2005 Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast to monomeric IAPP or mature fibrils) increase membrane permeability, suggesting an important ...
Bradshaw, Jeremy P. +14 more
core +1 more source
Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy
Nature Communications, 2019 Alzheimer’s disease (AD) is the most prevalent form of neurodegenerative disorders, yet no major breakthroughs have been made in AD human trials and the disease remains a paramount challenge and a stigma in medicine.
I. Javed +11 more
semanticscholar +1 more source
Amyloid Beta and MicroRNAs in Alzheimer’s Disease
Frontiers in Neuroscience, 2019 Alzheimer’s disease (AD) is a progressive mental illness characterized by memory loss and multiple cognitive impairments. In the last several decades, significant progress has been made in understanding basic biology, molecular mechanisms, and ...
N. Amakiri +3 more
semanticscholar +1 more source