Results 21 to 30 of about 1,555,922 (344)

Amyloid Beta in Aging and Alzheimer’s Disease

International Journal of Molecular Sciences, 2022
Alzheimer’s disease (AD), is a progressive neurodegenerative disease that affects behavior, thinking, learning, and memory in elderly individuals. AD occurs in two forms, early onset familial and late-onset sporadic; genetic mutations in PS1, PS2, and ...
Ujala Sehar, Priya Rawat, Arubala P. Reddy, J. Kopel, P. Reddy   +4 more
semanticscholar   +1 more source

Amyloid-beta and tau protein beyond Alzheimer’s disease

Neural Regeneration Research, 2023
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins
M. Abyadeh, V. Gupta, Joao A. Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Bala Gupta, Christine T. O. Nguyen, David I. Finkelstein, Yuyi You, Paul A. Haynes, G. H. Salekdeh, Stuart L. Graham, Mehdi Mirzaei   +13 more
semanticscholar   +1 more source

Microglia use TAM receptors to detect and engulf amyloid beta plaques

Nature Immunology, 2021
Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally.
Youtong Huang, Kaisa E Happonen, P. Burrola, Carolyn O’Connor, N. Hah, Ling Huang, A. Nimmerjahn, G. Lemke   +7 more
semanticscholar   +1 more source

Amyloid‐Beta Interaction with Mitochondria [PDF]

International Journal of Alzheimer’s Disease, 2011
Mitochondrial dysfunction is a hallmark of amyloid‐beta(Aβ)‐induced neuronal toxicity in Alzheimer′s disease (AD). The recent emphasis on the intracellular biology of Aβ and its precursor protein (AβPP) has led researchers to consider the possibility that mitochondria‐associated and/or intramitochondrial Aβ may directly cause neurotoxicity.
Pagani, Lucia, Eckert, Anne
openaire   +4 more sources

Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition

Journal of Neuroinflammation, 2021
Background Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer’s disease models; however, evidence of its occurrence in humans remains scarce.
Lisi Flores-Aguilar, M. Florencia Iulita, Chiara Orciani, Neil Tanna, Jingyun Yang, David A. Bennett, A. Claudio Cuello   +6 more
doaj   +1 more source

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. [PDF]

PLoS ONE, 2010
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population.
William J Netzer, Craig Powell, Yi Nong, Jacqueline Blundell, Lili Wong, Karen Duff, Marc Flajolet, Paul Greengard   +7 more
doaj   +1 more source

Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort

Molecular Brain, 2022
The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms.
Alexander S. Mihaescu, Mikaeel Valli, Carme Uribe, Maria Diez-Cirarda, Mario Masellis, Ariel Graff-Guerrero, Antonio P. Strafella   +6 more
doaj   +1 more source

β-Amyloid Monomers Are Neuroprotective [PDF]

The Journal of Neuroscience, 2009
The 42-aa-long β-amyloid protein—Aβ 1-42 —is thought to play a central role in the pathogenesis of Alzheimer's disease (AD) (Walsh and Selkoe, 2007). Data from AD brain (Shankar et al., 2008), transgenic APP (amyloid precursor protein)-overexpressing mice (Lesné et al., 2006), and neuronal ...
ML Giuffrida, F Caraci, B Pignataro, S Cataldo, P De Bona, V Bruno, G Molinaro, G Pappalardo, A Messina, A Palmigiano, D Garozzo, F Nicoletti, E Rizzarelli, A Copani   +13 more
openaire   +6 more sources

The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions

Biomedicines, 2023
Amyloid beta peptide is an important biomarker in Alzheimer’s disease, with the amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of dementia.
Thomas Gabriel Schreiner, Oliver Daniel Schreiner, Maricel Adam, Bogdan Ovidiu Popescu   +3 more
doaj   +1 more source

Synaptic Basis of Alzheimer’s Disease: Focus on Synaptic Amyloid Beta, P-Tau and Mitochondria

Ageing Research Reviews, 2020
Alzheimer’s disease (AD) is a progressive and synaptic failure disease. Despite the many years of research, AD still harbors many secrets. As more of the world’s population grows older, researchers are striving to find greater information on disease ...
Albin A John, P. Reddy
semanticscholar   +1 more source