Results 11 to 20 of about 1,555,922 (344)

Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease

Neural Regeneration Research, 2022
Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau ...
Alejandro R Roda, Gabriel Serra-Mir, Laia Montoliu-Gaya, Lidia Tiessler, Sandra Villegas   +4 more
doaj   +2 more sources

Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC [PDF]

Advanced Science, 2020
The gut–brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (Aβ), the pathogenic peptide associated with ...
Ibrahim Javed, Zhenzhen Zhang, Jozef Adamcik, Nicholas Andrikopoulos, Yuhuan Li, Daniel E. Otzen, Sijie Lin, Raffaele Mezzenga, Thomas P. Davis, Feng Ding, Pu Chun Ke   +10 more
doaj   +9 more sources

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients

Frontiers in Aging Neuroscience, 2020
Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Andres Villegas, Johannes Streffer, Marc Mercken   +2 more
exaly   +3 more sources

The amyloid-beta wave hypothesis of Alzheimer’s disease [PDF]

Frontiers in Cellular and Infection Microbiology
Alzheimer’s disease (AD) is a complex and multifactorial disorder that affects all races and genders. Genetic traits influenced by lifestyle and environment lead to a tremendous amount of heterogeneity in Alzheimer’s disease onset and severity ...
Sean J. Miller, Sean J. Miller, Robert Logan, Can Zhang, Brian P. Hafler, Brian P. Hafler, Brian P. Hafler   +6 more
doaj   +2 more sources

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Acta Neuropathologica, 2018
The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology.
Livia Civitelli, Max Larsson, Martin Ingelsson   +2 more
exaly   +2 more sources

Molecular simulations of amyloid beta assemblies

Advances in Physics: X, 2020
Several neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading tointracellular inclusions or extracellular aggregates in specific brain areas.
Gianvito Grasso, Andrea Danani
doaj   +2 more sources

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]

Neurodegenerative Diseases, 2009
Alzheimer-disease-associated β-amyloid (Aβ) is produced by sequential endoproteolysis of β-amyloid protein precursor (βAPP): the extracellular portion is shed by cleavage in the juxtamembrane region by β-amyloid-cleaving enzyme (BACE)/β-secretase, after which it is cleaved by presenilin (PS)/γ-secretase near the middle of the transmembrane domain. Thus,
Itoh, Naohiro, Okochi, Masayasu, Tagami, Shinji, Nishitomi, Kouhei, Nakayama, Taisuke, Yanagida, Kanta, Fukumori, Akio, Jiang, Jingwei, Mori, Kohji, Hosono, Motoko, Kikuchi, Jyunko, Nakano, Yuko, Takinami, Yoshihiko, Dohi, Keiji, Nishigaki, Atsuko, Takemoto, Hiroshi, Minagawa, Kazuyuki, Katoh, Takaaki, Willem, Michael, Haass, Christian, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Hasegawa, Hiroshi, Nishimura, Masaki, Sakaguchi, Gaku, Kato, Akira, Takeda, Masatoshi   +27 more
openaire   +5 more sources

Plasma pyroglutamate‐modified amyloid beta differentiates amyloid pathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Pyroglutamate‐modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra‐high‐sensitive assay is needed for detecting AβpE3‐40.
Pei‐Ning Wang, Kun‐Ju Lin, Huei‐Chun Liu, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Shieh‐Yueh Yang   +6 more
doaj   +4 more sources

Amyloid Alpha: The Neglected Cousin of Amyloid Beta. [PDF]

Chembiochem
For decades, amyloid β (Aβ) has been the principal therapeutic target for therapies of Alzheimer's disease (AD). An alternative processing product, known as P3, may form if the amyloid precursor protein is cleaved by α‐secretase instead of β‐secretase.
Raskatov JA.
europepmc   +2 more sources

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease

Frontiers in Neuroscience, 2019
Beta amyloid, Aβ 1–42, originally named as Amyloid A4 protein, is one of the most investigated peptides in neuroscience and has attracted substantial interest since its discovery as the main insoluble fibril-type protein in cerebrovascular amyloid ...
Heinz Hillen
doaj   +2 more sources