Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice [PDF]
Advanced Science, EarlyView.Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +2 more sources
Amyloid Alpha: The Neglected Cousin of Amyloid Beta [PDF]
ChemBioChemFor decades, amyloid β (Aβ) has been the principal therapeutic target for therapies of Alzheimer's disease (AD). An alternative processing product, known as P3, may form if the amyloid precursor protein is cleaved by α‐secretase instead of β‐secretase.
Raskatov JA.
openaire +3 more sources
The amyloid-beta wave hypothesis of Alzheimer’s disease [PDF]
Frontiers in Cellular and Infection MicrobiologyAlzheimer’s disease (AD) is a complex and multifactorial disorder that affects all races and genders. Genetic traits influenced by lifestyle and environment lead to a tremendous amount of heterogeneity in Alzheimer’s disease onset and severity ...
Sean J. Miller +6 more
doaj +2 more sources
Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]
, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory +2 more
core +5 more sources
Structural Studies of Cystatin B Amyloid Fibre and Oligomer [PDF]
, 2013 Amyloid fibres are characteristic of over 25 degenerative human diseases including Alzheimer’s and Parkinson’s disease. Amyloid fibres are insoluble, highly stable, ordered cross-β sheet structures, which form as a result of conformational change and ...
Davis, Peter J.
core +6 more sources
The copper-amyloid-beta-peptide complex of Alzheimer’s disease: affinity, structure, fibril formation and toxicity [PDF]
, 2010 PhDSenile plaques of Alzheimer’s disease (AD) patients are composed primarily of the amyloid-β-peptide peptide (Aβ), and within these plaques Cu2+ ions are found concentrated and directly bound to Aβ.
Sarell, Claire Jessica
core +4 more sources
Neurotoxicity of .BETA.-amyloid.
Folia Pharmacologica Japonica, 2000 Recent observations on the neurotoxicity of beta-amyloid have been reviewed and possible roles of racemization of beta-amyloid are discussed. beta 1-40, beta 25-35 and D-Ser26 beta 25-35 (all HCl salt forms), but not commercially available beta 1-40 (TFA salt form), take the beta-structure within few hours in PBS, form fibrils, exert toxic effects on ...
KANEKO, Isao +2 more
openaire +3 more sources
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]
, 2009 Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Nakano, Yuko +27 more
core +1 more source
Regulation of the metabolism of the Alzheimer's amyloid precursor protein by contactin 5 and BIN1 [PDF]
, 2012 Alzheimer’s disease (AD) is a progressive form of dementia, which currently has no cure. The metabolism of the amyloid precursor protein (APP) is an important determinant in the development of AD.
Glennon, Elizabeth Bernadette Claire
core +6 more sources
Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease
Frontiers in Aging Neuroscience, 2010 β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons.
Davide Tampellini
doaj +1 more source