Results 31 to 40 of about 1,107,227 (284)

Plasma pyroglutamate‐modified amyloid beta differentiates amyloid pathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Pyroglutamate‐modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra‐high‐sensitive assay is needed for detecting AβpE3‐40.
Pei‐Ning Wang, Kun‐Ju Lin, Huei‐Chun Liu, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Shieh‐Yueh Yang   +6 more
doaj   +1 more source

Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico. [PDF]

PLoS ONE, 2016
Amyloid-beta peptides have long been implicated in the pathology of Alzheimer's disease. Bexarotene, a drug approved by the U.S. Food and Drug Administration for treating a class of non-Hodgkin's lymphoma, has been reported to facilitate the removal of ...
Joseph Rosenthal, Georges Belfort, David Isaacson   +2 more
doaj   +1 more source

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

NeuroImage: Clinical, 2019
Background: Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks.
F.C. Quevenco, S.J. Schreiner, M.G. Preti, J.M.G. van Bergen, T. Kirchner, M. Wyss, S.C. Steininger, A. Gietl, S.E. Leh, A. Buck, K.P. Pruessmann, C. Hock, R.M. Nitsch, A. Henning, D. Van De Ville, P.G. Unschuld   +15 more
doaj   +1 more source

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

BMC Neuroscience, 2006
Background Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis.
Iwamoto Sean, Irwin Ronald W, Chen Shuhua, Nilsen Jon, Brinton Roberta   +4 more
doaj   +1 more source

Fibril fragmentation in amyloid assembly and cytotoxicity: When size matters [PDF]

, 2010
Amyloid assemblies are associated with several debilitating human disorders. Understanding the intra- and extracellular assembly of normally soluble proteins and peptides into amyloid aggregates and how they disrupt normal cellular functions is therefore
Xue, Wei-Feng, Hellewell, Andrew L., Hewitt, Eric W., Radford, Sheena E.   +3 more
core   +1 more source

The Contribution of S100B Suppression by Arundic Acid to the Inhibition of the Glio-Toxicity Induced by Beta-Amyloid in an Astrocytes Culture [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: It has been shown that glial activation has important role in the pathophysiology of Alzheimer’s disease. S100B is an astrocyte specific factor with deleterious effects on the neuronal and non-neuronal cells in the central nervous
Mahshid Hosseini, Mojtaba Keshavarz, Mahmood Vessal   +2 more
doaj  

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?

Neural Regeneration Research, 2022
Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj   +1 more source

Beta-amyloid imaging with florbetaben [PDF]

Clinical and Translational Imaging, 2015
Florbetaben is a fluorine-18 (18F)-labeled stilbene derivative that was developed as a positron emission tomography (PET) tracer for routine clinical application to visualize β-amyloid plaques in the Alzheimer's disease (AD) brain. The tracer successfully completed a global multicenter phase 0-III development program and was, as a consequence, recently
Sabri, O, Seibyl, J, Rowe, C, Barthel, H
openaire   +3 more sources

Molecular simulations of amyloid beta assemblies

Advances in Physics: X, 2020
Several neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading tointracellular inclusions or extracellular aggregates in specific brain areas.
Gianvito Grasso, Andrea Danani
doaj   +1 more source

Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity

Molecular Brain, 2020
Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles in the development of AD. Thus, considerable
Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth, Shiv Kumar Sharma   +5 more
doaj   +1 more source