Results 1 to 10 of about 274,232 (167)
The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions
Biomedicines, 2023 Amyloid beta peptide is an important biomarker in Alzheimer’s disease, with the amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of dementia.
Maricel Adam +2 more
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The amyloid-beta wave hypothesis of Alzheimer's disease. [PDF]
Front Cell Infect MicrobiolAlzheimer’s disease (AD) is a complex and multifactorial disorder that affects all races and genders. Genetic traits influenced by lifestyle and environment lead to a tremendous amount of heterogeneity in Alzheimer’s disease onset and severity ...
Miller SJ, Logan R, Zhang C, Hafler BP.
europepmc +2 more sources
Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
Neural Regeneration Research, 2022 Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau ...
Alejandro R Roda +4 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2020 Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Felix Dinkel +7 more
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Amyloid‐Beta Interaction with Mitochondria [PDF]
International Journal of Alzheimer’s Disease, 2011 Mitochondrial dysfunction is a hallmark of amyloid‐beta(Aβ)‐induced neuronal toxicity in Alzheimer′s disease (AD). The recent emphasis on the intracellular biology of Aβ and its precursor protein (AβPP) has led researchers to consider the possibility that mitochondria‐associated and/or intramitochondrial Aβ may directly cause neurotoxicity.
Pagani, Lucia, Eckert, Anne
openaire +4 more sources
Journal of Neuroinflammation, 2021 Background Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer’s disease models; however, evidence of its occurrence in humans remains scarce.
Lisi Flores-Aguilar +6 more
doaj +1 more source
Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. [PDF]
PLoS ONE, 2010 beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population.
William J Netzer +7 more
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Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
Molecular Brain, 2022 The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms.
Alexander S. Mihaescu +6 more
doaj +1 more source
Small-angle X-ray scattering characterization of a $$\beta $$ β -amyloid model in phantoms
BMC Research Notes, 2020 Objective We present a method to prepare an amyloid model at scalable quantities for phantom studies to evaluate small-angle x-ray scattering systems for amyloid detection. Two amyloid models were made from a plasma protein with and without heating. Both
Sophya Breedlove +3 more
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Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease
Frontiers in Aging Neuroscience, 2010 β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons.
Davide Tampellini
doaj +1 more source