Results 21 to 30 of about 1,107,761 (194)

Amyloid oligomer conformation in a group of natively folded proteins. [PDF]

PLoS ONE, 2008
Recent in vitro and in vivo studies suggest that destabilized proteins with defective folding induce aggregation and toxicity in protein-misfolding diseases.
Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima   +5 more
doaj   +1 more source

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance [PDF]

Frontiers in Aging Neuroscience, 2014
Accumulation of the amyloid-beta (Aβ) peptide is a central factor in Alzheimer's disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Aβ in AD before discussing the clearance of this peptide.
Marr, Robert A., Hafez, Daniel M.
openaire   +3 more sources

DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? [PDF]

PLoS ONE, 2011
Numerous reports have documented the beneficial effects of dietary docosahexaenoic acid (DHA) on beta-amyloid production and Alzheimer's disease (AD).
Zareen Amtul, Mary Keet, Lin Wang, Peter Merrifield, David Westaway, Richard F Rozmahel   +5 more
doaj   +1 more source

Plasma pyroglutamate‐modified amyloid beta differentiates amyloid pathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Pyroglutamate‐modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra‐high‐sensitive assay is needed for detecting AβpE3‐40.
Pei‐Ning Wang, Kun‐Ju Lin, Huei‐Chun Liu, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Shieh‐Yueh Yang   +6 more
doaj   +1 more source

Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner

Frontiers in Aging Neuroscience, 2020
Despite the extensive use of hormonal methods as either contraception or menopausal hormone therapy (HT), there is very little known about the potential effects of these compounds on the cellular processes of the brain.
Keyana N. Porter, Saumyendra N. Sarkar, Duaa A. Dakhlallah, Mya E. Vannoy, Dominic D. Quintana, James W. Simpkins, James W. Simpkins   +6 more
doaj   +1 more source

BETA AMYLOID POLYCLONAL ANTIBODY IMMUNOGENICITY AS EARLY DEVELOPMENT STUDY OF EARLY DIAGNOSIS FOR ALZHEIMER’S DISEASE

Malang Neurology Journal, 2017
Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversible neuronal cell loss, which can interfere with social and occupational functioning.
M. Rasjad Indra, Eko Arisetijono Marhendraputro, Rudi Rakhmad Hidayat   +2 more
doaj   +1 more source

Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC

Advanced Science, 2020
The gut–brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (Aβ), the pathogenic peptide associated with ...
Ibrahim Javed, Zhenzhen Zhang, Jozef Adamcik, Nicholas Andrikopoulos, Yuhuan Li, Daniel E. Otzen, Sijie Lin, Raffaele Mezzenga, Thomas P. Davis, Feng Ding, Pu Chun Ke   +10 more
doaj   +1 more source

Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico. [PDF]

PLoS ONE, 2016
Amyloid-beta peptides have long been implicated in the pathology of Alzheimer's disease. Bexarotene, a drug approved by the U.S. Food and Drug Administration for treating a class of non-Hodgkin's lymphoma, has been reported to facilitate the removal of ...
Joseph Rosenthal, Georges Belfort, David Isaacson   +2 more
doaj   +1 more source

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

NeuroImage: Clinical, 2019
Background: Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks.
F.C. Quevenco, S.J. Schreiner, M.G. Preti, J.M.G. van Bergen, T. Kirchner, M. Wyss, S.C. Steininger, A. Gietl, S.E. Leh, A. Buck, K.P. Pruessmann, C. Hock, R.M. Nitsch, A. Henning, D. Van De Ville, P.G. Unschuld   +15 more
doaj   +1 more source

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

BMC Neuroscience, 2006
Background Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis.
Iwamoto Sean, Irwin Ronald W, Chen Shuhua, Nilsen Jon, Brinton Roberta   +4 more
doaj   +1 more source