Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]
, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory +2 more
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Structural Studies of Cystatin B Amyloid Fibre and Oligomer [PDF]
, 2013 Amyloid fibres are characteristic of over 25 degenerative human diseases including Alzheimer’s and Parkinson’s disease. Amyloid fibres are insoluble, highly stable, ordered cross-β sheet structures, which form as a result of conformational change and ...
Davis, Peter J.
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The copper-amyloid-beta-peptide complex of Alzheimer’s disease: affinity, structure, fibril formation and toxicity [PDF]
, 2010 PhDSenile plaques of Alzheimer’s disease (AD) patients are composed primarily of the amyloid-β-peptide peptide (Aβ), and within these plaques Cu2+ ions are found concentrated and directly bound to Aβ.
Sarell, Claire Jessica
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Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]
, 2009 Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Nakano, Yuko +27 more
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Regulation of the metabolism of the Alzheimer's amyloid precursor protein by contactin 5 and BIN1 [PDF]
, 2012 Alzheimer’s disease (AD) is a progressive form of dementia, which currently has no cure. The metabolism of the amyloid precursor protein (APP) is an important determinant in the development of AD.
Glennon, Elizabeth Bernadette Claire
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Mitochondrial β-amyloid in Alzheimer's disease [PDF]
, 2011 This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA +20 more
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Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]
, 2006 Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
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Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
Molecular Neurodegeneration, 2009 Background The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and ...
O'Connor Peter B +4 more
doaj +1 more source
Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH. [PDF]
, 2002 BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen +5 more
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Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the receptor for advanced glycation end products [PDF]
, 2008 Amyloid beta (Aβ) has been postulated to be the principle initiator of the pathogenesis of Alzheimer’s disease (AD). Therefore, understanding the underlying mechanisms of Aβ induced neurotoxicity in the early stages of AD would be essential for finding ...
Ren, Yimin
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