Results 41 to 50 of about 1,107,761 (194)

Obstructive sleep apnea and amyloid-β42 in adolescents: The results of a pilot study

Acta Biomedica Scientifica, 2022
Background. Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive collapse of the upper airway during sleep leading to intermittent hypoxia, excessive arousals and disrupt of sleep homeostasis. OSA is associated with obesity as
O. N. Berdina, I. M. Madaeva, S. E. Bolshakova, L. F. Sholokhov, L. V. Rychkova   +4 more
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Polyphenolic Biflavonoids Inhibit Amyloid-Beta Fibrillation and Disaggregate Preformed Amyloid-Beta Fibrils [PDF]

Biomolecules & Therapeutics, 2019
Alzheimer's disease (AD) is a devastating neurodegenerative disease and a major cause of dementia in elderly individuals worldwide. Increased deposition of insoluble amyloid β (Aβ) fibrils in the brain is thought be a key neuropathological hallmark of AD.
Choi, Erika Y., Kang, Sam Sik, Lee, Sang Kook, Han, Byung Hee   +3 more
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Amyloid Beta in Aging and Alzheimer’s Disease

International Journal of Molecular Sciences, 2022
Alzheimer’s disease (AD), is a progressive neurodegenerative disease that affects behavior, thinking, learning, and memory in elderly individuals. AD occurs in two forms, early onset familial and late-onset sporadic; genetic mutations in PS1, PS2, and APP genes cause early onset familial AD, and a combination of lifestyle, environment and genetic ...
Ujala Sehar, Priyanka Rawat, Arubala P. Reddy, Jonathan Kopel, P. Hemachandra Reddy   +4 more
openaire   +2 more sources

Gold Nanoparticles Mediate Improved Detection of β-amyloid Aggregates by Fluorescence

Nanomaterials, 2020
The early detection of the amyloid beta peptide aggregates involved in Alzheimer’s disease is crucial to test new potential treatments. In this research, we improved the detection of amyloid beta peptide aggregates in vitro and ex vivo by fluorescence ...
Pedro Jara-Guajardo, Pablo Cabrera, Freddy Celis, Mónica Soler, Isadora Berlanga, Nicole Parra-Muñoz, Gerardo Acosta, Fernando Albericio, Fanny Guzman, Marcelo Campos, Alejandra Alvarez, Francisco Morales-Zavala, Marcelo J Kogan   +12 more
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Rheb-mTOR activation rescues Aβ-induced cognitive impairment and memory function by restoring miR-146 activity in glial cells

Molecular Therapy: Nucleic Acids, 2021
Deposition of amyloid beta plaques in adult rat or human brain is associated with increased production of proinflammatory cytokines by associated glial cells that are responsible for degeneration of the diseased tissue.
Dipayan De, Ishita Mukherjee, Subhalakshmi Guha, Ramesh Kumar Paidi, Saikat Chakrabarti, Subhas C. Biswas, Suvendra N. Bhattacharyya   +6 more
doaj   +1 more source

Hippocampal Beta-Amyloid Accumulation In Aluminium Chloride and D-Galactose-Induced Rats: Establishing a Nontransgenic Alzheimer’s Model

Journal of Pharmacy and Bioallied Sciences
Background: Alzheimer’s disease (AD) is characterized by tau protein aggregation and beta-amyloid (Aβ) plaques leading to progressive cognitive decline.
Thirupathirao Vishnumukkala, Samaila M. Chiroma, Saravanan Jagadeesan, Prarthana K. Gopalakrishna, Sreenivasulu Sura, Nurul H. Mohd Nor, Mohamad A. Mohd Moklas   +6 more
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Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles

International Journal of Nanomedicine, 2010
Sun-Ho Han1, Yu Jin Chang1, Eun Sun Jung1, Jong-Won Kim2, Duk Lyul Na3, Inhee Mook-Jung11Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Jongro-gu, Seoul, Korea; 2Department of Laboratory Medicine and ...
Sun-Ho Han, Yu Jin Chang, Eun Sun Jung, et al   +3 more
doaj  

BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis.

PLoS Computational Biology, 2009
Amyloids and prion proteins are clinically and biologically important beta-structures, whose supersecondary structures are difficult to determine by standard experimental or computational means.
Allen W Bryan, Matthew Menke, Lenore J Cowen, Susan L Lindquist, Bonnie Berger   +4 more
doaj   +1 more source

Molecular Cloning and Expression of Osmotin in a Baculovirus-Insect System: Purified Osmotin Mitigates Amyloid-beta Deposition in Neuronal Cells

Scientific Reports, 2017
Osmotin is a pathogenesis-related plant protein, have gained focus of research because of its homology with mammalian adiponectin. The therapeutic properties of osmotin have been explored in recent years as it exhibits neuroprotective effects against ...
Noman Bin Abid, Gwangho Yoon, Myeong Ok Kim   +2 more
doaj   +1 more source