Results 51 to 60 of about 1,555,922 (344)

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

NeuroImage: Clinical, 2019
Background: Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks.
F.C. Quevenco, S.J. Schreiner, M.G. Preti, J.M.G. van Bergen, T. Kirchner, M. Wyss, S.C. Steininger, A. Gietl, S.E. Leh, A. Buck, K.P. Pruessmann, C. Hock, R.M. Nitsch, A. Henning, D. Van De Ville, P.G. Unschuld   +15 more
doaj   +1 more source

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

BMC Neuroscience, 2006
Background Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis.
Iwamoto Sean, Irwin Ronald W, Chen Shuhua, Nilsen Jon, Brinton Roberta   +4 more
doaj   +1 more source

Molecules that Target beta‐Amyloid

ChemMedChem, 2007
AbstractThe devastating effects of Alzheimer’s and related amyloidogenic diseases have inspired the synthesis and evaluation of numerous ligands to understand the molecular mechanism of the aggregation of the beta‐amyloid peptide. Our review focuses on the current knowledge in this field with respect to molecules that have been demonstrated to interact
Stains, Cliff I., Mondal, Kalyani, Ghosh, Indraneel   +2 more
openaire   +3 more sources

Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to CNS amyloidosis

Alzheimer's & Dementia, 2017
Cerebrospinal fluid analysis and other measurements of amyloidosis, such as amyloid‐binding positron emission tomography studies, are limited by cost and availability.
Vitaliy Ovod, Kara N Ramsey, K. Mawuenyega, James G. Bollinger, Terry J. Hicks, Theresa Schneider, Melissa Sullivan, K. Paumier, David M. Holtzman, J. Morris, T. Benzinger, Anne M. Fagan, Bruce W. Patterson, R. Bateman   +13 more
semanticscholar   +1 more source

Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-beta(38/40/42) in Frontotemporal Dementias and Primary Progressive Aphasias [PDF]

, 2010
Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25 ...
Hermann Esselmann, Mirko Bibl, Johannes Kornhuber, Markus Otto, Esselmann, Hermann, Rüther, Eckart, Otto, Markus, Lewczuk, Piotr, Kornhuber, Johannes, Eckart Rüther, Piotr Lewczuk, Brit Mollenhauer, Bibl, Mirko, Wolf, Stefanie, Jens Wiltfang, Mollenhauer, Brit, Wiltfang, Jens, Stefanie Wolf   +17 more
core   +1 more source

The Contribution of S100B Suppression by Arundic Acid to the Inhibition of the Glio-Toxicity Induced by Beta-Amyloid in an Astrocytes Culture [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: It has been shown that glial activation has important role in the pathophysiology of Alzheimer’s disease. S100B is an astrocyte specific factor with deleterious effects on the neuronal and non-neuronal cells in the central nervous
Mahshid Hosseini, Mojtaba Keshavarz, Mahmood Vessal   +2 more
doaj  

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?

Neural Regeneration Research, 2022
Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj   +1 more source

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

Nature Medicine, 2018
Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer’s disease. Unraveling the genetic background for the regional vulnerability of these proteinopathies can help in understanding the mechanisms of pathology progression.
J. Sepulcre, Michel J. Grothe, F. d’Oleire Uquillas, Laura Ortiz-Terán, I. Díez, Hyun-Sik Yang, H. Jacobs, Bernard J. Hanseeuw, Quanzheng Li, G. El-Fakhri, R. Sperling, Keith A. Johnson   +11 more
semanticscholar   +1 more source

Mitochondrial β-amyloid in Alzheimer's disease

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Conway, SJ, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway   +20 more
core   +1 more source

Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity

Molecular Brain, 2020
Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles in the development of AD. Thus, considerable
Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth, Shiv Kumar Sharma   +5 more
doaj   +1 more source