Results 281 to 290 of about 118,464 (350)

The Role of Selection for Function in Aging and Chronic Diseases: A Novel Evolutionary Perspective

Aging Cell, EarlyView.
This conceptual diagram shows how aging alters selection within the body: strong early‐life Darwinian selection prevents aberrant structures, while weakened selective pressure in later life allows persistent damage‐related entities to stabilize. These may reorganize internally, becoming resistant, under a late‐life “selection for function” that favors ...
Antoine M. Dujon, Klara Asselin, Jean François Lemaître, Jean‐Pascal Capp, Pascal Pujol, Beata Ujvari, James DeGregori, Aurora M. Nedelcu, Frédéric Thomas   +8 more
wiley   +1 more source

Alzheimer’s amyloid beta peptides disturb circadian oscillations of intracellular calcium concentration

, 2013
Anna Kaźmierczak, Karen Schmitt, Anna Grimm, Joanna B. Strosznajder, A Eckert   +4 more
openalex   +1 more source

APP Induces AICD‐Mediated Autophagy‐Dependent Axon Degeneration

Aging Cell, EarlyView.
In the adult Drosophila wing, amyloid precursor protein (APP) promotes axon degeneration through its intracellular domain (AICD) via an autophagy‐dependent pathway. The transcription factor dFoxO is essential for APP/AICD‐induced autophagy and plays a critical role in mediating the resulting neurodegeneration.
Jingjing Luo, Yu Qiu, Yu Pan, Ruihong Xu, Yi Sun, Yihao Sun, Luming Zhuang, Elleen Xue, Wenzhe Li, Qian Zhou, Zhongwei Lv, Chenglin Li, Lei Xue   +12 more
wiley   +1 more source

Targeting Amyloid-β Proteins as Potential Alzheimer's Disease Therapeutics: Anti-Amyloid Drug Discovery, Emerging Therapeutics, Clinical Trials and Implications for Public Health. [PDF]

Pharmaceuticals (Basel)
Abduljawad AA, Alkinani KB, Zaakan A, AlGhamdi AS, Hamdoon AAE, Alshanbari BH, Alshehri AA, Alluhaybi BB, Alqashi SOI, Abduljawad RA.   +9 more
europepmc   +1 more source

Genetic Reduction of the Translational Repressors FMRP and 4E‐BP2 Preserves Memory in Mouse Models of Alzheimer's Disease

Aging Cell, EarlyView.
Genetic reduction of the translational repressors FMRP or 4E‐BP2 prevents amyloid‐β oligomer–induced suppression of hippocampal protein synthesis and memory loss in mice. Targeting translational control preserves cognitive function in Alzheimer's models, revealing mRNA translation as a promising therapeutic axis for memory preservation.
Felipe C. Ribeiro, Danielle Cozachenco, Michael Parkhill, Brandon Rodrigue, Caio Borges, Jean‐Claude Lacaille, Karim Nader, Fernanda G. De Felice, Mychael V. Lourenco, Argel Aguilar‐Valles, Nahum Sonenberg, Sergio T. Ferreira   +11 more
wiley   +1 more source

A systematic review of brain health in adults with chronic pain

Anaesthesia, EarlyView.
Summary Introduction Recent research has linked chronic pain with an increased risk of clinical dementia diagnosis. Yet structural and functional brain changes associated with chronic pain and their potential role in accelerating brain ageing have not been characterised comprehensively.
Angeline Lee, Sara Al‐Dahwi, Thomas Angell, Abinaya Arulalagan, Ryan Bloxsom, Harry Clarkson, Rose Faure, Soutiam Goodarzi, Minshu Gupta, Adithya Kale, Kin Lam, Freyia Mahon‐Daly, Chloe Parry, Vidushi Pradhan, Finlay Ryan‐Phillips, Suraj Shah, Serina Sidhu, John Smiddy, Aparna Sridhar, Syed F. Tahmid, Robert Wight, Nia Roberts, Anya Topiwala   +22 more
wiley   +1 more source

Synthetic deformylated α-helical PSMα3 as a selective inhibitor of human amyloid aggregation. [PDF]

Sci Rep
Kalitnik A, Wojciechowska AW, Wojciechowski JW, Polańska O, Sareło P, Szefczyk M, Kotulska M.   +6 more
europepmc   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Impulse Dyscontrol Symptoms Are Related to Amyloid Beta in Patients With Subjective Cognitive Decline and Mild Cognitive Impairment. [PDF]

Psychogeriatrics
Rochetti ALG, Ribeiro IC, Barnes LL, Rizzi L, Aventurato IK, Gonçalves BC, da Silva MCR, Balthazar MLF.   +7 more
europepmc   +1 more source

Activity of Peptides Modulating the Action of p2x Receptors: Focus on the p2x7 Receptor. [PDF]

Pharmaceuticals (Basel)
De Souza Oliveira Carneiro JA, Teixeira GP, Rocha L, Faria RX.   +3 more
europepmc   +1 more source