Results 261 to 270 of about 109,107 (305)
Alzheimer's Disease and the Amyloid-β Peptide [PDF]
Journal of Alzheimer's Disease, 2010 Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology in the human brain and the degree of clinical dementia.
Murphy M. Paul, LeVine, III Harry
openaire +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Cholesterol Trafficking and Amyloid Beta Peptides
Pharmacopsychiatry, 2003Currently, there is much interest in the association between cholesterol and Alzheimer's disease. An especially important aspect of this association is the relationship between amyloid beta-peptide (Abeta) and cholesterol that can be described as a reciprocal process.
W G, Wood, U, Igbavboa
openaire +2 more sources
Amyloid beta peptides electrochemistry: A review
Current Opinion in Electrochemistry, 2022Abstract Alzheimer disease is a progressive age-related neurodegenerative disorder estimated to affect up to 107 million people by 2050, its pathology is associated with the dysfunction of the amyloid beta (Aβ) peptide mechanism, among others. Electrochemical methods were successfully applied for Aβ electrochemical characterisation and have received ...
Ana-Maria Chiorcea-Paquim +1 more
openaire +1 more source
ACS Chemical Neuroscience, 2018 Inhibition of the self-assembly process of amyloid-beta and even more the removal of already existing toxic amyloid-beta assemblies represent promising therapeutic strategies against Alzheimer’s disease.
Tamar Ziehm +2 more
exaly +2 more sources
Amyloid beta peptide immunotherapy in Alzheimer disease
Revue Neurologique, 2014Recent advances in the understanding of Alzheimer's disease pathogenesis have led to the development of numerous compounds that might modify the disease process. Amyloid β peptide represents an important molecular target for intervention in Alzheimer's disease.
J, Delrieu +3 more
openaire +2 more sources
Interfacial Effects on the Conformation of Amyloid-Beta Peptide
Protein & Peptide Letters, 2009We examined the effects of air-water and water-sevoflurane interfaces on conformational properties of amyloid-beta peptide (ABP). Fractions were extracted from sub-interfacial (air-water) and supra-interfacial (water-sevoflurane) layers and compared with aqueous bulk layers using fluorescence properties of ABP provided by a single tyrosine.
Norbert W, Seidler, Joshua D, Eklund
openaire +2 more sources
Amyloid Beta Peptide Folding in Reverse Micelles
Journal of the American Chemical Society, 2017Previously published experimental studies have suggested that when the 40-residue amyloid beta peptide is encapsulated in a reverse micelle, it folds into a structure that may nucleate amyloid fibril formation (Yeung, P. S.-W.; Axelsen, P. H. J. Am. Chem. Soc. 2012, 134, 6061 ).
Gözde Eskici, Paul H Axelsen
openaire +2 more sources
Amyloid beta peptides and glutamatergic synaptic dysregulation
Experimental Neurology, 2008Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of glutamatergic synaptic ...
Kodeeswaran, Parameshwaran +2 more
openaire +2 more sources
In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides
2012The amyloid beta Ab(1-40) and Ab(1-42) peptides are the main components of the fibrillar plaques characteristically found in the brains affected by Alzheimer's disease. Fibril formation has been thoroughly studied in vitro using synthetic amyloid peptides and has been described to be a nucleation dependent polymerization process.
Núria, Benseny-Cases +2 more
openaire +2 more sources
Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis
Current Alzheimer Research, 2006Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4 ...
Mark A, Lovell, William R, Markesbery
openaire +2 more sources