Results 281 to 290 of about 109,107 (305)
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Protection against amyloid beta peptide toxicity by zinc
Brain Research, 1999Zinc (Zn) is an essential element in normal development and biology, although it is toxic at high concentrations. Recent studies show that Zn at high concentrations accelerates aggregation of amyloid beta peptide (Abeta), the major component of senile plaques in Alzheimer's disease (AD).
M A, Lovell, C, Xie, W R, Markesbery
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Separation and characterization of aggregated species of amyloid-beta peptides
Analytical and Bioanalytical Chemistry, 2010We have investigated the use of isoelectric focusing and immunodetection for the separation of low molecular weight species of amyloid-beta (Abeta) peptides from their aggregates. From solutions of Abeta(1-40) or Abeta(1-42) monomeric peptides, low molecular weight material appeared at a pI value of ca.
Henning, Wiberg +5 more
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[Structure of amyloid-beta peptides in a complex with model membranes].
Tsitologiia, 2014Structures of amyloid-beta peptides Aβ1-40, Aβ10-35, Aβ13-23 and Aβ16-22 in a complex with model membranes in solution were obtained on the analysis of NMR experimental data. It has been established that the process of peptide-micelle complex formation occurs through the amino acid residues L17, F19, F20 and G29-M35.
Usachev K., Filippov A., Klochkov V.
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Conformations and Biological Activities of Amyloid Beta Peptide 25-35
Current Protein & Peptide Science, 2009Amyloid-beta (Abeta) peptide is commonly found in human Alzheimer's disease (AD) brain and is the main component of Alzheimer amyloid plaques. The predominant forms of Abeta in the human brain are Abeta(1-40) and Abeta(1-42), but Abeta(25-35) fragment, physiologically present in elderly people, is the more toxic region and has been recently found to ...
Millucci, Lia +3 more
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Amyloid-beta peptides are cytotoxic to oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Amyloid-beta peptide (Abeta), a 39-43 amino acid peptide derived from beta-amyloid precursor protein, forms insoluble fibrillar aggregates that have been linked to neuronal and vascular degeneration in AD and cerebral amyloid angiopathy.
J, Xu +6 more
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Intracellular biology of Alzheimer's disease amyloid beta peptide
European Archives of Psychiatry and Clinical Neuroscience, 1999Strong evidence links excess production of a small peptide and the pathogenesis of Alzheimer's disease (AD). Originally this peptide, beta-amyloid 42 (Abeta42), was assumed to be released by a pathogenic event; it is now well established that Abeta42 is released from cells during normal cellular metabolism of the Alzheimer amyloid precursor protein ...
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Amyloid beta-peptide: the inside story.
Current Alzheimer research, 2005The amyloid beta-peptide (Abeta) plays an early and critical role in the pathogenic cascade leading to Alzheimer's disease (AD). Abeta is typically found in extracellular amyloid plaques that occur in specific brain regions in the AD and Down syndrome brain.
Bertrand P, Tseng +2 more
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Effect of nanoparticles on the aggregation and amyloid formation of amyloid-beta peptide
Biophysical Journal, 2023Éva Moussong +7 more
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