Results 271 to 280 of about 109,107 (305)

Natural human antibodies to amyloid beta peptide

Autoimmunity Reviews, 2008
Properties of human, natural anti-Abeta antibodies and commercially available intravenous immunoglobulin (IVIg) have been examined in light of the beneficial effects of passive immunotherapy with IVIg for patients with mild to moderate Alzheimer's disease (AD).
Paul, Szabo, Norman, Relkin, Marc E, Weksler   +2 more
openaire   +2 more sources

Diversity of amyloid beta peptide actions

Reviews in the Neurosciences
Abstract Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer’s disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight.
Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan   +2 more
openaire   +2 more sources

Effect of ferric citrate on amyloid‐beta peptides behavior

Biopolymers, 2018
AbstractAmyloid beta (Aβ) aggregation and oxidative stress are two of the central events in Alzheimer's Disease (AD). Both these phenomena can be caused by the interaction of Aβ with metal ions. In the last years the interaction between ZnII, CuII, and Aβ was much studied, but between iron and Aβ it is still little known.
Galante D, Cavallo E, Perico A, D'Arrigo C   +3 more
openaire   +2 more sources

Sequestration of amyloid beta-peptide.

Annals of the New York Academy of Sciences, 1993
Amyloid beta-protein, or beta/A4, is a 4-kilodalton peptide that forms poorly soluble extracellular depositions of amyloid in brains and leptomeninges of patients with Alzheimer's disease (AD), Down's syndrome (DS), and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D).
D, Goldgaber, A I, Schwarzman, R, Bhasin, L, Gregori, D, Schmechel, A M, Saunders, A D, Roses, W J, Strittmatter   +7 more
openaire   +1 more source

Cholesterol Modulates Amyloid Beta-peptide’s Membrane Interactions

Pharmacopsychiatry, 2003
The causal relationship between amyloid beta-peptide (Abeta) deposition and Alzheimer's disease (AD)-specific neuropathological lesions such as neurodegeneration and cortical atrophy is still not known. Mounting evidence points to alterations in cholesterol homeostasis occurring in AD brain that are probably linked to cerebral Abeta pathology ...
Gunter P, Eckert, Christopher, Kirsch, Steffen, Leutz, W Gibson, Wood, Walter E, Müller   +4 more
openaire   +2 more sources

Interaction of Calreticulin with Amyloid Beta Peptide 1-42

Protein & Peptide Letters, 2008
The interaction of calreticulin with amyloid beta (Abeta) was investigated using solid phase and solution binding assays. Calreticulin bound Abeta 1-42 in a time and concentration dependent fashion. The binding was optimal at pH 5 and was stimulated by Ca2+ and inhibited by Zn2+ at pH 7.
Duus, K., Hansen, Paul Robert, Houen, G.
openaire   +3 more sources

Monitoring the amyloid beta-peptide in vivo – caveat emptor

Drug Discovery Today, 2009
As a wave of 'disease modifying' (DM) therapies for Alzheimer's disease (AD) progresses towards the later stages of clinical development, an evaluation of our ability to measure relevant pharmacodynamic effects of such therapies is warranted. Reducing accumulation of amyloid beta (Abeta)-peptide in the brain parenchyma is the primary objective of most ...
Paul W, Thompson, Andrew, Lockhart
openaire   +2 more sources

Amyloid beta peptide directly inhibits PKC activation

Molecular and Cellular Neuroscience, 2004
A putative protein kinase C (PKC) pseudosubstrate domain in beta amyloid (Abeta) suggests a potential interaction between Abeta and PKC. In this study, we investigated whether and how Abeta interacts with PKC. Abeta peptides inhibited PKC phosphorylation in a dose-dependent manner in cell-free in vitro condition, suggesting a direct interaction between
Lee, W, Boo, JH, Jung, MW, Park, SD, Kim, YH, Kim, SU, Mook-Jung, I   +6 more
openaire   +3 more sources

Radiolabeling of Amyloid-β Peptides

2005
Nowadays, a wide variety of protocols for labeling proteins is available. However, radiolabeling remains one of the most powerful, sensitive and accurate methods to trace and quantitate proteins. Additionally, radiolabeling techniques are steadily gaining importance for diagnosis and treatment in nuclear medicine.
Miguel, Calero, Jorge, Ghiso
openaire   +2 more sources

Oxidative Modification of Glutamine Synthetase by Amyloid Beta Peptide

Free Radical Research, 1997
beta-Amyloid peptide (A beta), the main constituent of senile plaques and diffuse amyloid deposits in Alzheimer's diseased brain, was shown to initiate the development of oxidative stress in neuronal cell cultures. Toxic lots of A beta form free radical species in aqueous solution.
M Y, Aksenov, M V, Aksenova, J M, Carney, D A, Butterfield   +3 more
openaire   +2 more sources