Results 271 to 280 of about 117,808 (299)

Brain membrane cholesterol domains, aging and amyloid beta-peptides

Neurobiology of Aging, 2002
Lipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly distributed but are localized in different domains. These domains consist of the exofacial and cytofacial leaflets, cholesterol pools, annular lipids, and lipid rafts.
W Gibson, Wood, Friedhelm, Schroeder, Urule, Igbavboa, Nicolai A, Avdulov, Svetlana V, Chochina   +4 more
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Monitoring the amyloid beta-peptide in vivo – caveat emptor

Drug Discovery Today, 2009
As a wave of 'disease modifying' (DM) therapies for Alzheimer's disease (AD) progresses towards the later stages of clinical development, an evaluation of our ability to measure relevant pharmacodynamic effects of such therapies is warranted. Reducing accumulation of amyloid beta (Abeta)-peptide in the brain parenchyma is the primary objective of most ...
Paul W, Thompson, Andrew, Lockhart
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Interfacial Effects on the Conformation of Amyloid-Beta Peptide

Protein & Peptide Letters, 2009
We examined the effects of air-water and water-sevoflurane interfaces on conformational properties of amyloid-beta peptide (ABP). Fractions were extracted from sub-interfacial (air-water) and supra-interfacial (water-sevoflurane) layers and compared with aqueous bulk layers using fluorescence properties of ABP provided by a single tyrosine.
Norbert W, Seidler, Joshua D, Eklund
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Amyloid beta-peptide: the inside story.

Current Alzheimer research, 2005
The amyloid beta-peptide (Abeta) plays an early and critical role in the pathogenic cascade leading to Alzheimer's disease (AD). Abeta is typically found in extracellular amyloid plaques that occur in specific brain regions in the AD and Down syndrome brain.
Bertrand P, Tseng, Masashi, Kitazawa, Frank M, LaFerla   +2 more
openaire   +1 more source

Interaction of Calreticulin with Amyloid Beta Peptide 1-42

Protein & Peptide Letters, 2008
The interaction of calreticulin with amyloid beta (Abeta) was investigated using solid phase and solution binding assays. Calreticulin bound Abeta 1-42 in a time and concentration dependent fashion. The binding was optimal at pH 5 and was stimulated by Ca2+ and inhibited by Zn2+ at pH 7.
Duus, K., Hansen, Paul Robert, Houen, G.
openaire   +3 more sources

Amyloid beta peptide-activated signal pathways in human platelets

European Journal of Pharmacology, 2008
Amyloid beta peptide (amyloid-beta), which accumulates in the cerebral microvessels in an age-dependent manner, plays a key role in the pathogenesis of cerebral amyloid angiopathy. Platelets are an important cellular element in vasculopathy of various causes. Amyloid-beta may activate or potentiate platelet aggregation.
Ming Y, Shen, George, Hsiao, Tsorng H, Fong, Hui M, Chen, Duen S, Chou, Chien H, Lin, Joen R, Sheu, Chung Y, Hsu   +7 more
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Amyloid-beta peptides are cytotoxic to oligodendrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Amyloid-beta peptide (Abeta), a 39-43 amino acid peptide derived from beta-amyloid precursor protein, forms insoluble fibrillar aggregates that have been linked to neuronal and vascular degeneration in AD and cerebral amyloid angiopathy.
J, Xu, S, Chen, S H, Ahmed, H, Chen, G, Ku, M P, Goldberg, C Y, Hsu   +6 more
openaire   +1 more source

Amyloid Beta Peptide Processing, Insulin Degrading Enzyme, and Butyrylcholinesterase

Neurochemical Research, 2001
Amyloid beta peptide implicated in Alzheimers disease is cleaved by insulin degrading enzyme (IDE). Abnormal cholinesterases similar to butyrylcholinesterase (BChE) are found in Alzheimer brain. The similarities between IDE and BChE (which is known to have an arylacylamidase and a metallocarboxypeptidase-like activity) such as their zinc metalloenzyme ...
openaire   +2 more sources

Peptidases, proteases and amyloid beta-peptide catabolism.

Current pharmaceutical design, 2003
The formation of senile plaques containing amyloid beta peptides (Abeta peptides) as a major constituent plays a significant role in development of Alzheimer's disease. The concentration of Abeta peptides in the brain is determined by a combination of their rate of synthesis and their rate of clearance.
openaire   +1 more source

Detection of amyloid beta peptides in body fluids for the diagnosis of alzheimer’s disease: Where do we stand?

Critical Reviews in Clinical Laboratory Sciences, 2020
Chrisophe Hirtz, Constance Delaby, Christophe Hirtz   +2 more
exaly