Results 321 to 330 of about 120,218 (348)

Amyloid-beta peptides are cytotoxic to oligodendrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Amyloid-beta peptide (Abeta), a 39-43 amino acid peptide derived from beta-amyloid precursor protein, forms insoluble fibrillar aggregates that have been linked to neuronal and vascular degeneration in AD and cerebral amyloid angiopathy.
J, Xu, S, Chen, S H, Ahmed, H, Chen, G, Ku, M P, Goldberg, C Y, Hsu   +6 more
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Amyloid Beta Peptide Processing, Insulin Degrading Enzyme, and Butyrylcholinesterase

Neurochemical Research, 2001
Amyloid beta peptide implicated in Alzheimers disease is cleaved by insulin degrading enzyme (IDE). Abnormal cholinesterases similar to butyrylcholinesterase (BChE) are found in Alzheimer brain. The similarities between IDE and BChE (which is known to have an arylacylamidase and a metallocarboxypeptidase-like activity) such as their zinc metalloenzyme ...
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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Chemical Reviews, 2021
Phuong H Nguyen, Ayyalusamy Ramamoorthy, Bikash Sahoo   +2 more
exaly  

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes

Chemical Reviews, 2021
Danilo Milardi, Ehud Gazit, Sheena E Radford   +2 more
exaly  

Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids

Chemical Reviews, 2021
Dieter Willbold, Birgit Strodel, Gunnar F. Schröder   +2 more
exaly  

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Nature Reviews Drug Discovery, 2022
Eric Karran, Bart De Strooper
exaly  

Peptidases, proteases and amyloid beta-peptide catabolism.

Current pharmaceutical design, 2003
The formation of senile plaques containing amyloid beta peptides (Abeta peptides) as a major constituent plays a significant role in development of Alzheimer's disease. The concentration of Abeta peptides in the brain is determined by a combination of their rate of synthesis and their rate of clearance.
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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future

Signal Transduction and Targeted Therapy, 2023
Weihong Song
exaly  

[Amyloid beta peptide].

Nihon rinsho. Japanese journal of clinical medicine, 2005
Hisatomo, Kowa, Takeshi, Iwatsubo
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Amyloid beta-peptide

2006
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