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Amyloid-beta peptides are cytotoxic to oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Amyloid-beta peptide (Abeta), a 39-43 amino acid peptide derived from beta-amyloid precursor protein, forms insoluble fibrillar aggregates that have been linked to neuronal and vascular degeneration in AD and cerebral amyloid angiopathy.
J, Xu +6 more
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Amyloid beta-peptide: the inside story.
Current Alzheimer research, 2005The amyloid beta-peptide (Abeta) plays an early and critical role in the pathogenic cascade leading to Alzheimer's disease (AD). Abeta is typically found in extracellular amyloid plaques that occur in specific brain regions in the AD and Down syndrome brain.
Bertrand P, Tseng +2 more
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Intracellular biology of Alzheimer's disease amyloid beta peptide
European Archives of Psychiatry and Clinical Neuroscience, 1999Strong evidence links excess production of a small peptide and the pathogenesis of Alzheimer's disease (AD). Originally this peptide, beta-amyloid 42 (Abeta42), was assumed to be released by a pathogenic event; it is now well established that Abeta42 is released from cells during normal cellular metabolism of the Alzheimer amyloid precursor protein ...
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[Structure of amyloid-beta peptides in a complex with model membranes].
Tsitologiia, 2014Structures of amyloid-beta peptides Aβ1-40, Aβ10-35, Aβ13-23 and Aβ16-22 in a complex with model membranes in solution were obtained on the analysis of NMR experimental data. It has been established that the process of peptide-micelle complex formation occurs through the amino acid residues L17, F19, F20 and G29-M35.
Usachev K., Filippov A., Klochkov V.
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Effect of nanoparticles on the aggregation and amyloid formation of amyloid-beta peptide
Biophysical Journal, 2023Éva Moussong +7 more
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Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids
Chemical Reviews, 2021Dieter Willbold +2 more
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Nature Reviews Drug Discovery, 2022Eric Karran, Bart De Strooper
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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Signal Transduction and Targeted Therapy, 2023Weihong Song
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