Results 331 to 340 of about 94,035 (378)
Some of the next articles are maybe not open access.
Expression of Alzheimer Amyloid Beta-Protein Precursor Gene in Neuronal Cells
Gerontology, 1991Five forms of Alzheimer amyloid beta-protein precursors (APP or BPP) have been found. Among them, APP695 is predominantly found in neuronal cells and may be involved in some neuronal functions. In the present work, we investigated the relationship between the APP expression and the formation of neurites, a typical neuronal morphology, by measuring the ...
Hiroyuki Sasaki +5 more
openaire +3 more sources
Zhonghua yi xue za zhi, 2005
To observe the expression of amyloid beta precursor protein and amyloid beta protein in neurons of hippocampal CA1 region after brain ischemia in human.Neuronal damage was examined by using HE staining, and expression of APP and Abeta(1-40) was determined by immunohistochemistry in the hippocampal CA1 region of the brain specimens of 43 patients who ...
Ji-ping Qi +3 more
openaire +3 more sources
To observe the expression of amyloid beta precursor protein and amyloid beta protein in neurons of hippocampal CA1 region after brain ischemia in human.Neuronal damage was examined by using HE staining, and expression of APP and Abeta(1-40) was determined by immunohistochemistry in the hippocampal CA1 region of the brain specimens of 43 patients who ...
Ji-ping Qi +3 more
openaire +3 more sources
Stimulated platelets release amyloid β-protein precursor
Biochemical and Biophysical Research Communications, 1990Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of ...
I. Paul Shapiro +3 more
openaire +3 more sources
Amyloid β-protein precursor is associated with extracellular matrix
Brain Research, 1990The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.
F.G. Klier +3 more
openaire +3 more sources
Isoform Specific Amyloid-β Protein Precursor Metabolism
Journal of Alzheimer's Disease, 2007Alzheimer's amyloid-beta protein precursor (AbetaPP) can occur in different isoforms, among them AbetaPP(751), which is the most abundant isoform in non-neuronal tissues, and AbetaPP(695), often referred to as the neuronal isoform. However, few isoform-specific roles have been addressed. In the work here described, AbetaPP isoforms, both endogenous and
Sara C.T.S. Domingues +5 more
openaire +3 more sources
Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)
Science, 1990Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by extensive amyloid deposition in the small leptomeningeal arteries and cortical arterioles, which lead to an early death of those afflicted in their fifth or sixth decade ...
Egbert Bakker +8 more
openaire +4 more sources
Life Sciences, 1990
The amyloid A4 (or beta protein), a 4.2 kD polypeptide, is a major component of amyloid deposits in the brains of patients with Alzheimer's Disease (AD). The self-aggregating amyloid A4 protein of AD is encoded as part of three larger proteins by the amyloid A4 precursor gene. The corresponding proteins have 695, 751 and 770 amino acid residues.
Hossein A. Ghanbari +2 more
openaire +3 more sources
The amyloid A4 (or beta protein), a 4.2 kD polypeptide, is a major component of amyloid deposits in the brains of patients with Alzheimer's Disease (AD). The self-aggregating amyloid A4 protein of AD is encoded as part of three larger proteins by the amyloid A4 precursor gene. The corresponding proteins have 695, 751 and 770 amino acid residues.
Hossein A. Ghanbari +2 more
openaire +3 more sources
Studies of Amyloid β‐Protein Precursor Expression in Alzheimer's Disease
Annals of the New York Academy of Sciences, 1991The generation of the beta/A4 peptide and its accumulation into insoluble amyloid deposits represent key events in the neuropathologic process of Alzheimer's disease (AD). This posit has gained further support from recent reports that beta/A4 is directly responsible for the death of neurons. Potential therapies for AD aimed at abating the production of
Rudolph E. Tanzi, Bradley T. Hyman
openaire +3 more sources
Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease
Annual Review of Cell Biology, 1994BIOCHEMICAL ANALYSES OF ALZHEIMER BRAIN LESIONS LEAD TO THE IDENTIFICATION OF A AND ITS PRECURSOR . . . . . . . . . . . . . . . . . . . 374 The Histopathology of Alzheimer's Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 374 Characterization of A and pp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
openaire +3 more sources
Science, 1994
Normal processing of the amyloid β protein precursor (βAPP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid β protein (Aβ) that forms insoluble fibrillar deposits in Alzheimer's disease.
Xiao Dan Cai +7 more
openaire +3 more sources
Normal processing of the amyloid β protein precursor (βAPP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid β protein (Aβ) that forms insoluble fibrillar deposits in Alzheimer's disease.
Xiao Dan Cai +7 more
openaire +3 more sources