Results 91 to 100 of about 249,317 (377)
Crucial role of non-specific interactions in amyloid nucleation [PDF]
, 2014 Protein oligomers have been implicated as toxic agents in a wide range of amyloid-related diseases. Yet it has remained unsolved whether the oligomers are a necessary step in the formation of amyloid fibrils, or just a dangerous by-product. Analogously, it has not been resolved if the amyloid nucleation process is a classical one-step nucleation ...
arxiv +1 more source
The hidden hand of lipids in the amyloid cascade [PDF]
arXiv, 2022 Intrinsically disordered proteins (IDPs), such as amyloid polypeptide (IAPP), beta-amyloid (A\b{eta}), and {\alpha}-synuclein are linked to the insurgence of type 2 diabetes, Alzheimer's, and Parkinson's diseases, respectively. Common molecular mechanisms have been explored to elucidate the toxicity pathway of these proteins.
arxiv
Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit [PDF]
, 2012 Background: The pathogenesis of Alzheimer’s disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-beta and secondary vessel degeneration.
Busch, Stephanie +5 more
core +1 more source
Down syndrome, beta-amyloid and neuroimaging
Free Radical Biology and Medicine, 2018 This review focuses on the role of Aβ in AD pathogenesis in Down syndrome and current approaches for imaging Aβ in vivo. We will describe how Aβ deposits with age, the posttranslational modifications that can occur, and detection in biofluids. Three unique case studies describing partial trisomy 21 cases without APP triplication, and the occurrences of
Head, Elizabeth +3 more
openaire +5 more sources
Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimer's disease and tau pathology. Dual‐phase 11C‐PiB PET detects amyloid deposition and cerebral perfusion changes and may have diagnostic value for identifying tau in CAA ...
Meng‐Ting Chiang +4 more
wiley +1 more source
Sensors, 2018 Determination of the conformation (monomer, oligomer, or fibril) of amyloid peptide aggregates in the human brain is essential for the diagnosis and treatment of Alzheimer’s disease (AD).
Dahye Jeong +11 more
doaj +1 more source
Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives [PDF]
PeerJ, 2015 A range of diseases is associated with amyloid fibril formation. Despite different proteins being responsible for each disease, all of them share similar features including beta-sheet-rich secondary structure and fibril-like protein aggregates.
Tomas Šneideris +5 more
doaj +2 more sources
Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism [PDF]
, 2014 The aggregation and accumulation of the amyloid beta peptide in the brain is hypothesized to be an initial necessary event in the pathogenesis of Alzheimer\u27s disease (AD).
Basak, Jacob Martin
core +1 more source
Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype. [PDF]
, 2021 In-vitro studies of autosomal dominant Alzheimer's disease implicate longer amyloid-beta peptides in disease pathogenesis, however less is known about the behaviour of these mutations in-vivo.
Abel, E +20 more
core
Resveratrol and Amyloid-Beta: Mechanistic Insights
Nutrients, 2017 The amyloid-beta (Aβ) hypothesis that dyshomeostasis between Aβ production and clearance is a very early, key molecular factor in the etiology of Alzheimer’s disease (AD) has been proposed and examined in the AD research field. Scientists have focused on seeking natural products or drugs to influence the dynamic equilibrium of Aβ, targeting production ...
Yongming Jia, Na Wang, Xuewei Liu
openaire +3 more sources