Results 261 to 270 of about 376,147 (348)

Protective effects of Dendrobium nobile Lindl. alkaloids on amyloid beta (25–35)-induced neuronal injury

, 2017
Jing-Shan Shi, Wei Zhang, Qin Wu, Yan-Liu Lu, Qihai Gong, Feng Zhang   +5 more
openalex   +1 more source

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

ChemistryEurope, EarlyView.
Amyloid‐selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments.
Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma, Motomu Kanai   +11 more
wiley   +1 more source

Cerebellar White Matter Microstructure Is Associated With Age, Cerebrospinal Fluid Amyloid Beta Levels, and Cognition in Cognitively Unimpaired Older Adults. [PDF]

Hum Brain Mapp
Paitel ER, Pettigrew C, Callow DD, Moghekar A, Miller MI, Faria AV, Oishi K, Albert M, Soldan A.   +8 more
europepmc   +1 more source

Evaluation of a New Methylimidazole‐Containing Thiosemicarbazone as a Cu+/Cu2+‐Targeting Ligand in the Context of Alzheimer's Disease

Chemistry – A European Journal, EarlyView.
HXE modulates Cu(Aβ) interaction, reducing ROS production and shifting peptide aggregation in the presence of Cu from toxic amorphous aggregates to less harmful fibrillar structures. These findings highlight HXE potential to interfere with Cu‐induced oxidative stress and aggregation pathways relevant to AD.
Barbara Marinho Barbosa, Charlène Esmieu, Antal Galvácsi, Mariana Viana Costa, Adèle Brison, Sonia M. Ladeira, Jade de Oliveira, Csilla Kállay, Christelle Hureau, Nicolás A. Rey   +9 more
wiley   +1 more source

Beta amyloid peptides accumulation induces the over expression of TSPO translocator in optic nerve, visual cortex and in the retina in Alzheimer s disease and aging model

, 2017
Luis F Hernandez, Abigail Torres, Monserrat Perez, Elisa Gorostieta, Miriam Catorce, Gonzalo Acero, Goar Gevorkian, Ruben Zamora, Hugo Quiroz   +8 more
openalex   +1 more source

In Situ Observation of Polyoxometalate Formation by Vibrational Spectroscopy

Chemistry – A European Journal, EarlyView.
In‐situ IR and Raman spectroscopy were employed to observe the formation of polyoxometalates (POMs) in aqueous solution. Thereby key intermediates were identified, and better understanding of POM formation enabled the development of an improved method for the synthesis of vanadium‐substituted phosphomolybdates, which are important catalysts for ...
Jan‐Dominik H. Krueger, Jan‐Christian Raabe, Zainab Yusufzadeh, Andreas Berger, Jakob Albert, Maximilian J. Poller   +5 more
wiley   +1 more source

Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer's Disease. [PDF]

Int J Mol Sci
Pokrzyk J, Kulczyńska-Przybik A, Guzik-Makaruk E, Winkel I, Mroczko B.   +4 more
europepmc   +1 more source

The effect of Edaravone on Amyloid beta aggregation

, 2019
Elina Berntsson
openalex   +1 more source

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, EarlyView.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzio, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations. [PDF]

Alzheimers Dement
McVea A, DiFilippo A, McLachlan M, Betcher B, Zammit M, Betthauser TJ, Converse A, Murali D, Stone C, Hartley S, Johnson S, Tudorascu DL, Laymon CM, Cohen AD, Minhas D, Luo W, Mathis C, Lao PJ, Ances B, Zaman S, Mapstone M, Head E, Handen BL, Christian BT, ABC‐DS investigators.   +24 more
europepmc   +1 more source