Results 261 to 270 of about 249,317 (377)

Proportions of Basement Membrane Proteins in Cerebrovascular Smooth Muscle Cells After Exposure to Hypercapnia and Amyloid Beta. [PDF]

Cells
Dewing JM, Keable A, Laslo A, Chinezu L, Ivanescu A, Ratnayaka JA, Kalaria R, Slevin M, Verma A, Carare RO.   +9 more
europepmc   +1 more source

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain [PDF]

, 2001
Harry F. Dovey, Varghese John, J. P. Anderson, L. Z. Chen, P. D. S. int Andrieu, Lanlan Fang, Stephen B. Freedman, B. Folmer, Erich Goldbach, Elzbieta J. Holsztynska, Kang Hu, Kelly Johnson‐Wood, S. L. Kennedy, Dora Kholodenko, Jeroen Knops, Lee H. Latimer, M. Lee, Zhengchang Liao, Ivan Lieberburg, Ruth Motter, Linda Mutter, J. Nietz, Kevin P. Quinn, K. L. Sacchi, Peter Seubert, George M. Shopp, Eugene D. Thorsett, Jay S. Tung, Jing Wu, Shao-Hua Yang, Chen Yin, Dale B. Schenk, Patrick C. May, L. Altstiel, Mark H. Bender, Leonard N. Boggs, T. C. Britton, James C. Clemens, Dan L. Czilli, Donna K. Dieckman-McGinty, J. J. Droste, Kimberly S. Fuson, Bruce D. Gitter, Paul A. Hyslop, Edward M. Johnstone, W‐Y. Li, Sharon Little, Thomas E. Mabry, F. DeWolfe Miller, B. Ni, Jeffrey S. Nissen, Warren J. Porter, B D Potts, Jon K. Reel, Diane Stephenson, Yuan Su, Lisa A. Shipley, Celia A. Whitesitt, Tao Yin, James E. Audia   +59 more
openalex   +1 more source

Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives

Chemistry &Biodiversity, EarlyView.
ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos, Marie Demonceaux, Lucia Emanueli Schimith, Marine Goux, Claude Solleux, Ana Luiza Muccillo‐Baisch, Bruno Dutra Arbo, Corinne Andre‐Miral, Mariana Appel Hort   +8 more
wiley   +1 more source

Ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicology of the subfamily Gomphrenoideae (Amaranthaceae): A comprehensive review

Chemistry &Biodiversity, Accepted Article.
The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves, Giulia Cristina Andreoli de Souza, Alvaro Jose Hernandez Tasco, Marcos Jose Salvador   +3 more
wiley   +1 more source

Dual modulation of amyloid beta and tau aggregation and dissociation in Alzheimer's disease: a comprehensive review of the characteristics and therapeutic strategies. [PDF]

Transl Neurodegener
Nam Y, Shin SJ, Kumar V, Won J, Kim S, Moon M.   +5 more
europepmc   +1 more source

A New Compound (AZ36041) Promotes the Survival of the Neurons and Reduces Neurotoxicity of Alzheimer's Beta-Amyloid Protein.

, 1995
Yasushi Hasegawa, Emika SUGIMOTO, Tomoko Endo, Kohei Ogawa, Hisashi Aratake, Anri MORIKAWA, Nobuya Kitaguchi   +6 more
openalex   +2 more sources

Nitroxyl Hybrids with Curcumin and Stilbene Scaffolds Display Potent Antioxidant Activity, Remodel the Amyloid Beta Oligomer, and Reverse Amyloid Beta-Induced Cytotoxicity. [PDF]

Antioxidants (Basel)
Budamagunta MS, Mori H, Silk J, Slez RR, Bognár B, Mendiola UR, Kálai T, Maezawa I, Voss JC.   +8 more
europepmc   +1 more source

SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core

ChemBioChem, EarlyView.
The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic, Djenana Vejzovic, Altea Topciu, Kirill Kuhlmann, Raj Kumar, Maria Andrea Mroginski, Alejandra de Miguel, Pia Hofmann, Klaus Zangger, Markus Weingarth, Robert A. Cordfunke, Jan W. Drijfhout, Peter Nibbering, Michal Belicka, Karl Lohner, Nermina Malanovic   +15 more
wiley   +1 more source

Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application

Chronic Diseases and Translational Medicine, EarlyView.
Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash, Karthikeyan Elumalai   +1 more
wiley   +1 more source

Pycnogenol Protects Vascular Endothelial Cells from .BETA.-Amyloid-Induced Injury.

, 2000
F. J. Liu, Benjamin H.S. Lau, Qiaoling Peng, Vandana SHAH   +3 more
openalex   +2 more sources