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Amyloid Beta: The Alternate Hypothesis
Current Alzheimer Research, 2006Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and scientists are eager to decipher the underlying disease mechanism and, thereafter, target this therapeutically. Most investigators studying the underlying cause of AD have focused on amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the ...
Hyoung-gon, Lee +4 more
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Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor
Journal of Alzheimer's Disease, 2002Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing of the amyloid β protein precursor (AβPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent ...
Xie, Ling +4 more
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The international journal of biochemistry & cell biology, 1999
Amyloid beta (A beta) is a 39-43 residue amyloidogenic peptide that is deposited into the extracellular amyloid plaques which characterize an Alzheimer's disease (AD) brain. A beta is derived from the amyloid precursor protein (APP) and undergoes a toxic conformational change (gain of toxic function).
R, Cappai, A R, White
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Amyloid beta (A beta) is a 39-43 residue amyloidogenic peptide that is deposited into the extracellular amyloid plaques which characterize an Alzheimer's disease (AD) brain. A beta is derived from the amyloid precursor protein (APP) and undergoes a toxic conformational change (gain of toxic function).
R, Cappai, A R, White
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Beta-amyloid immunisation in Alzheimer’s disease
Neurological Sciences, 2005Beta-amyloid immunisation in Alzheimer's ...
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Brain : a journal of neurology, 2003
The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
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The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
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Neuro-degenerative diseases, 2007
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of ...
Finder VH, Glockshuber R
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Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of ...
Finder VH, Glockshuber R
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2023
Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
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Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
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Functional neurology, 1993
beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
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beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
openaire +1 more source