Results 181 to 190 of about 160,241 (252)
Inhibitory Activity of Red Panda Islet Amyloid Polypeptide on Human IAPP Aggregation
Journal of Peptide Science, Volume 32, Issue 12, December 2026.The figure shows the comparison of (a) human islet amyloid polypeptide (hIAPP) self‐assembling into a fibril structure and (b) a model of hIAPP self‐assembling in the presence of red panda islet amyloid polypeptide (IAPP). The figure was produced from PDB file 6Y1A using Swiss PDB viewer software.
Lauren Phillips +5 more
wiley +1 more source
On the Need to Revise the Amyloid Cascade Hypothesis
ChemBioChem, Volume 27, Issue 21, 12 November 2026.Past research in the Alzheimer’s disease field has focused much of its efforts on the amyloid beta peptide, dismissing the shorter, alternative processing product called P3 is soluble, non‐toxic and not relevant to disease. This manuscript refutes the notion that P3 is innocuous and calls for a thorough re‐evaluation of its relevance in Alzheimer’s ...
David B. Teplow, Jevgenij A. Raskatov
wiley +1 more source
ChemMedChem, Volume 21, Issue 21, 12 November 2026.Bi‐thiophene‐vinyl‐benzothiazolium (bTVBT) ligands with distinct amino acid functionalities displayed differential binding to protein aggregates in human brain tissue sections with Alzheimer's disease pathology. bTVBT‐G‐OMe showed staining of GT‐38‐positive tau aggregates, whereas staining was weaker for bTVBT‐E‐diOMe.
Linnea Björk +5 more
wiley +1 more source
Fibrilpaint: A Class of Amyloid‐Targeting Peptides
Chemistry – A European Journal, Volume 32, Issue 41, 3 November 2026.FibrilPaints are modular peptides engineered to recognize amyloid fibrils. By systematically varying charge, sequence, and termini, their binding behavior can be tuned while retaining recognition. Successful binding ″paints″ fibrils for visualization and opens routes toward targeted degradation and diagnostic applications.
Júlia Aragonès Pedrola +8 more
wiley +1 more source
All‐Amyloid Functional Coacervates
Advanced Materials, Volume 38, Issue 61, 2 November 2026.This study introduces an all‐amyloid interfacial complex coacervate technique that employs charge‐mediated or functionalization‐assisted complexation of oppositely charged food protein‐derived amyloid nanofibrils to engineer functional soft constructs across multiple length scales.
Seyyed Alireza Hashemi +4 more
wiley +1 more source
Culinary Chemistry as a Platform for Interfacial Materials Design
Advanced Materials Interfaces, Volume 13, Issue 21, 6 November 2026.Culinary processes control interfaces through heating, shear, gelation, and molecular transport. This Review connects selected gastronomic examples with food‐derived nanomaterials, plasmonic sensing, anthocyanin photovoltaics, and intelligent packaging. Original agar‐based plasmonic films illustrate the proposed translation.
Josep Moreno +12 more
wiley +1 more source
α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, Volume 13, Issue 62, 9 November 2026.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel +10 more
wiley +1 more source
Push–pull hypothesis of Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.Abstract The “push–pull” hypothesis of Alzheimer's disease (AD) emerges from a careful examination of the key discoveries over the past 40 years. Specifically, amyloid beta (Aβ) plays a direct role impairing endolysosome activity in neurons and microglia, promoting the collapse of proteostasis, reducing tau degradation, and facilitating the cell‐to ...
Matthew Townsend
wiley +1 more source
Age‐linked biological context shapes adaptive immunity in Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.Abstract Alzheimer's disease (AD) is increasingly recognized as a neuroimmune disorder with protective or pathogenic adaptive immunity dependent on the biological context. This review synthesizes evidence from human studies, genetic analyses, mouse models, and clinical trials to examine how lymphocytes and humoral immunity influence AD.
Sophie Shirenova +2 more
wiley +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 11, November 2026.The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen +8 more
wiley +1 more source