Results 191 to 200 of about 160,241 (252)

Polyglycine Strands Within a Collagen Triple Helix

Biopolymers, Volume 117, Issue 6, November 2026.
ABSTRACT The collagen triple helix is the most abundant protein structural motif in animals. It tolerates any amino acid in its Xaa and Yaa positions but demands glycine (Gly) at every third position, where the residue packs into the sterically forbidding core of the triple helix and donates the recurring interstrand N–H⋯OC hydrogen bond that stitches
Wasin Tiarawut, Gabriel Saenz, Jinyi Yang, Ronald T. Raines   +3 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Molecular Hybrids Incorporating Coumarin‐Pyrazole‐Linked Indolinone Derivatives With Antioxidant and Anti‐Alzheimer Properties

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
ABSTRACT The increase in global life expectancy has resulted in a significant rise in the occurrence of Alzheimer's disease (AD), making it a critical public health burden. Therefore, there is an urgent need to create effective methods to prevent or slow down the progression of the disease.
Ahmed Sabt, Wael Mahmoud Aboulthana, Abdulrahman M. Saleh, Hoda Atef Abdelsattar Ibrahim, Asmaa Saleh, Xinsheng Lei, Aladdin M. Srour   +6 more
wiley   +1 more source

Intrathecal Transplantation of Human Umbilical Cord‐Derived MSCs Outperforms Intravenous Administration in Attenuating Pathology and Cognitive Deficits in Alzheimer's Disease Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Mesenchymal stem cell therapy is a promising approach for Alzheimer's disease, yet the optimal delivery route remains unclear. Using the 5xFAD mouse model, we performed a head‐to‐head comparison of intrathecal and intravenous transplantation of human umbilical cord–derived mesenchymal stem cells. Intrathecal delivery more effectively improved cognition,
Li Ding, Wei Yu, Yuqian Chen, Hu Wang, Shuya Li, Hanyu Li, Tianyu Shu, Xiaohe Huang, Ying Yang, Rui Liu, Xinglin Liu, Zhibing Ai, Xingrong Guo, Jun Chen, Qiumin Qu   +14 more
wiley   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source

Hybrid Confocal Fluorescence and Photoacoustic Microscopy for In‐Depth and Noninvasive Imaging of Biomolecule‐Functionalized 3D Scaffolds

Journal of Biophotonics, Volume 19, Issue 11, November 2026.
Illustration of 3D scaffold fabrication and functionalization with amyloid peptide fibrils, followed by nondestructive characterization using hybrid confocal fluorescence and photoacoustic microscopy. These complementary imaging modalities enable detailed visualization of scaffold architecture and selective detection of peptide fibrils, providing a ...
Eudokia Kyriakou, George J. Tserevelakis, Konstantina Terzaki, Petros Tavlas, Chrysanthi Pinelopi Apostolidou, Stefanos Mavrikos, Costas P. Grigoropoulos, Anna Mitraki, Maria Farsari, Giannis Zacharakis   +9 more
wiley   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Amyloid Fibril Interaction [PDF]

, 2020
openaire   +1 more source

Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source

Mechanochemically Programmed, Oligomer‐Selective Amyloid Assembly via Axial Rotation

Small, Volume 22, Issue 61, 2 November 2026.
Tunable axial rotation mechanically redirects amyloid assembly without chemical additives. Low rotational speeds favor fibril maturation, whereas high‐speed rotation suppresses productive fibril amplification and biases the pathway toward oligomer‐enriched assemblies.
Seokbeom Roh, Eunji Song, Minwoo Bae, Da Yeon Cheong, Sechan Han, Taeha Lee, Dain Kang, Jae Eon Lee, Seung Pil Pack, Hyungbeen Lee, Insu Park, Gyudo Lee   +11 more
wiley   +1 more source

Self‐Assembly of Hierarchically Structured Materials From Liquid Crystalline Mesophases of Tobacco Mosaic Virus‐Like Particles

Small, Volume 22, Issue 62, 6 November 2026.
Recombinantly produced Tobacco Mosaic Virus coat protein (TMVcp) helical rods were demonstrated to reproducibly self‐assemble into hierarchically structured macroscopic filaments, driven by a lyotropic liquid crystal (LC) intermediate phase. The results indicate anisotropic molecular alignment of the fluid phase, retention of the native secondary ...
Guido M. Merino, Matthew J. Harrington, Amy Szuchmacher Blum   +2 more
wiley   +1 more source