Results 91 to 100 of about 252,333 (374)

NeuroAiD® (MLC601) and Amyloid Precursor Protein Processing [PDF]

Cerebrovascular Diseases, 2013
<b><i>Background:</i></b> Amyloid precursor protein (APP) undergoes cleavage under physiological conditions, predominantly by α- and &#947;-secretases, to form the nonpathogenic sAPPα and p3 fragments. By contrast, amyloid-beta (Aβ) is produced via proteolytic cleavage by β- and &#947;-secretases. In Alzheimer's disease (
Lim, YA, Murray, LA, Lai, MKP, Chen, C
openaire   +3 more sources

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics

Advanced Science, EarlyView.
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing, Ruohong Wang, Tianzhang Kou, Wenbin Liu, Zheng‐Jiang Zhu   +4 more
wiley   +1 more source

Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

Neurobiology of Disease, 2005
Most transgenic mice used for preclinical evaluation of potential disease-modifying treatments of Alzheimer's disease develop major histopathological features of this disease by several-fold overexpression of the human amyloid precursor protein.
Christoph Köhler, Ulrich Ebert, Karlheinz Baumann, Hannsjörg Schröder   +3 more
doaj  

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

Aggregate, EarlyView.
The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal   +11 more
wiley   +1 more source

PDB_Amyloid: The Extended Live Amyloid Structure List from the PDB [PDF]

arXiv, 2018
The Protein Data Bank (PDB) contains more than 135 000 entries today. From these, relatively few amyloid structures can be identified, since amyloids are insoluble in water. Therefore, mostly solid state NMR-recorded amyloid structures are deposited in the PDB.
arxiv  

Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

Clinics, 2011
Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid ...
Evelin L. Schaeffer, Micheli Figueiro, Wagner F. Gattaz   +2 more
doaj   +1 more source

Cross‐Linked Protein Crystals With an Intense Nonconventional Full‐Color Photoluminescence Originating From Through‐Space Intermolecular Interaction

Aggregate, EarlyView.
Cross‐linked protein crystals are introduced as a novel class of nontraditional luminescent materials (NLMs) exhibiting tunable full‐color photoluminescence. Three polymorphic lysozyme crystals establish a clear, definitive structure–emission relationship, revealing that emission originates from intermolecular through‐space interactions (TSI).
Renbin Zhou, Xiaoli Lu, Xuefeng Zhou, Xuejiao Liu, Shanmin Wang, Tymish Y. Ohulchanskyy, Da‐Chuan Yin, Junle Qu   +7 more
wiley   +1 more source

Why Abeta42 Is Much More Toxic Than Abeta40 [PDF]

arXiv, 2018
Amyloid precursor with 770 amino acids dimerizes and aggregates, as do its c terminal 99 amino acids and amyloid 40,42 amino acids fragments. The titled question has been discussed extensively, and here it is addressed further using thermodynamic scaling theory to analyze mutational trends in structural factors and kinetics.
arxiv  

The Budapest Amyloid Predictor and its Applications [PDF]

arXiv, 2020
The amyloid state of proteins is widely studied with relevancy in neurology, biochemistry, and biotechnology. In contrast with amorphous aggregation, the amyloid state has a well-defined structure, consisting of parallel and anti-parallel $\beta$-sheets in a periodically repeated formation.
arxiv