Results 91 to 100 of about 82,488 (290)
Analysis of Amyloid Precursor Protein function in Drosophila melanogaster
Frontiers in Molecular Neuroscience, 2016 The Amyloid precursor protein (APP) has mainly been investigated in connection with its role in Alzheimer’s disease due to its cleavage resulting in the production of the Aβ peptides that accumulate in the plaques characteristic for this disease. However,
Doris Kretzschmar
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A Drosophila model of prion disease and its metabolic changes in the brain
Animal Models and Experimental Medicine, EarlyView.We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang +14 more
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Effects of Gene Imbalance on Amyloid Precursor Protein [APP] Expression in Grafts and Recipient Cortex [PDF]
, 1992 Christine F. Höhmann +2 more
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Animal Models and Experimental Medicine, EarlyView.Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica +4 more
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Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, EarlyView.Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel +10 more
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Neural Regeneration ResearchA reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer’s disease. Consequently, enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression ...
Biao Xiao +8 more
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Advanced NanoBiomed Research, EarlyView.A neuron‐targeting drug delivery system is developed by incorporating the tau‐specific N‐amino peptide, mxyl‐NAP2, with graphene quantum dots (GQDs) and encapsulating the complex into small extracellular vesicles functionalized with a neuron‐targeting ligand.
Runyao Zhu +5 more
wiley +1 more source
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Neurobiology of Disease, 2009 Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in gene transcriptional control, could be involved in the development of sporadic Alzheimer's disease (AD ...
Sébastien S. Hébert +6 more
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Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. [PDF]
, 1991 Mark J. Adler +4 more
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Angewandte Chemie International Edition, EarlyView.The intricate glycosylation pattern of human Pentraxin‐2 (PTX‐2) poses a challenge in studying the structural impact of individual glycans. By combining surface‐induced dissociation (SID) or unfolding (SIU) with ion mobility mass spectrometry, we successfully differentiated the stability of glycoengineered PTX‐2 variants.
Philipp Bittner +7 more
wiley +1 more source