Cytoprotective functions of amyloid precursor protein family members in stress signaling and aging [PDF]
, 2013 Poster presentation: Molecular Neurodegeneration: Basic biology and disease pathways Cannes, France. 10-12 September 2013. Background: The amyloid precursor protein (APP) is processed via two different metabolic pathways: the amyloidogenic and the non ...
Chang, Steffi +4 more
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Evidence of endothelial dysfunction in the development of Alzheimer's disease : Is Alzheimer's a vascular disorder? [PDF]
, 2013 Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship.
Kelleher, Rory J., Soiza, Roy L
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Monoaminergic Neuropathology in Alzheimer's disease [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira +11 more
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Insights into Alzheimer disease pathogenesis from studies in transgenic animal models
Clinics, 2011 Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid ...
Evelin L. Schaeffer +2 more
doaj +1 more source
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]
, 2019 Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P +9 more
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Possible roles of amyloid intracellular domain of amyloid precursor protein
BMB Reports, 2010 Amyloid precursor protein (APP), which is critically involved in the pathogenesis of Alzheimer's disease (AD), is cleaved by gamma/epsilon-secretase activity and results in the generation of different lengths of the APP Intracellular C-terminal Domain (AICD).
Yoo-Hun Suh, Keun-A Chang
openaire +4 more sources
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
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The amyloid hypothesis of Alzheimer's disease at 25 years
EMBO Molecular Medicine, 2016 Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early,
D. Selkoe, J. Hardy
semanticscholar +1 more source
Neurobiological pathways to Alzheimer's disease: Amyloid-beta, TAU protein or both?
Dementia & NeuropsychologiaAlzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, including memory loss, behavioral and psychological symptoms and personality changes.
Vanessa de Jesus R. de Paula +3 more
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Amyloid Precursor Protein Trafficking, Processing, and Function*
Journal of Biological Chemistry, 2008 Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades.
G. Thinakaran, E. Koo
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