Results 111 to 120 of about 175,143 (304)

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. [PDF]

, 2018
Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used
Fong, Lauren K, Frankowski, Harald, Goldstein, Lawrence SB, Petsko, Gregory A, Small, Scott A, Young, Jessica E   +5 more
core   +3 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Possible roles of amyloid intracellular domain of amyloid precursor protein

BMB Reports, 2010
Amyloid precursor protein (APP), which is critically involved in the pathogenesis of Alzheimer's disease (AD), is cleaved by gamma/epsilon-secretase activity and results in the generation of different lengths of the APP Intracellular C-terminal Domain (AICD).
Keun-A, Chang, Yoo-Hun, Suh
openaire   +3 more sources

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease

Frontiers in Neurology, 2017
Alzheimer’s disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system.
Juanjuan Zhao, Dongxu Yue, Ya Zhou, Li Jia, Hairong Wang, Mengmeng Guo, Hualin Xu, Chao Chen, Jidong Zhang, Lin Xu   +9 more
doaj   +1 more source

Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models

AGING MEDICINE, EarlyView.
CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke, Amrei Vivian Purwien, Annik Steiert, Henrike Hasecke, Yvonne Bouter   +4 more
wiley   +1 more source

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media

Annals of Neurology, EarlyView.
Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe   +11 more
wiley   +1 more source

SYSTEMIC AMYLOIDOSIS: FINDING ON AUTOPSY. REPORT OF TWO CASES (IN SPANISH)

Revista Ciencias Biomédicas, 2014
Introduction: amyloidosis is the extracellular accumulation of amyloid material, which causes damage in the functioning of organs and tissues. It is characterized by the presence of protein folding, which acquire the capacity of self-assembly creating
Martínez-Muñoz Elsa, Baena-Del Valle Javier, Barrios-Barreto Rina, Herrera-Lomonaco Sandra, Redondo-Bermúdez César, Miranda-Marzola María del Carmen   +5 more
doaj