Results 131 to 140 of about 120,581 (311)

The copper-amyloid-beta-peptide complex of Alzheimer’s disease: affinity, structure, fibril formation and toxicity

, 2010
PhDSenile plaques of Alzheimer’s disease (AD) patients are composed primarily of the amyloid-β-peptide peptide (Aβ), and within these plaques Cu2+ ions are found concentrated and directly bound to Aβ.
Sarell, Claire Jessica
core  

Physiological role of amyloid precursor protein during neural development

, 2017
Amyloid precursor protein (APP) is a type-one membrane-spanning protein with a large extracellular N-terminal domain and a small intracellular C-terminal domain.
Banote, Rakesh Kumar
core   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2.

, 2012
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Russell, CL, Claire L Russell, Beesley, PW, Sophia Semerdjieva, Ruth M Empson, Semerdjieva Sophia, Brian M Austen, Empson, RM, Austen Brian M., Empson Ruth M., Russell Claire L., Philip W Beesley, Alifragis Pavlos, Beesley Philip W., Semerdjieva, S, Alifragis, P, Pavlos Alifragis, Austen, BM   +17 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century

, 2015
The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer's disease patients.
Navarro Brugal, Gemma, Martínez-Pinilla, Eva, Franco Fernández, Rafael, Moreno Guillén, Estefanía   +3 more
core   +1 more source

Design and commissioning of a new synchrotron beamline dedicated to X‐ray footprinting mass spectrometry

Journal of Synchrotron Radiation, EarlyView.
A dedicated beamline at the Advanced Light Source synchrotron has been opened and commissioned for X‐ray footprinting mass spectrometry.The structural biology method of X‐ray footprinting mass spectrometry (XFMS) is available at two national synchrotron beamlines in the USA: one at the Advanced Light Source (ALS) on the West Coast and the other at the ...
Sayan Gupta, Brandon Russell, Line G. Kristensen, Jared de Chant, Anthony Lu, Lieselotte Obst-Huebl, Behzad Rad, James Tyler, Simruthi Subramanian, Savannah Kidd, Sathi Paul, Yan Chen, Christopher J. Petzold, Darren N. Kahan, Shawn M. Costello, Kei Nakamura, Jamie L. Inman, Alastair A. MacDowell, Adrian Spucces, Corie Y. Ralston   +19 more
wiley   +1 more source

Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the receptor for advanced glycation end products

, 2008
Amyloid beta (Aβ) has been postulated to be the principle initiator of the pathogenesis of Alzheimer’s disease (AD). Therefore, understanding the underlying mechanisms of Aβ induced neurotoxicity in the early stages of AD would be essential for finding ...
Ren, Yimin
core  

Helical reconstruction of amyloids in cryoSPARC

Acta Crystallographica Section F, EarlyView.
We present practical guidelines for helical reconstruction of amyloid filaments in cryoSPARC, benchmarked against publicly available datasets. Our analysis defines current capabilities and limitations, and outlines optimization strategies to enable high‐throughput structural studies and therapeutic discovery.Amyloid‐mediated proteotoxicity underlies ...
Jan-Hannes Schaefer, Robert T. O'Neill, Joseph P. Donnelly, Evan T. Powers, Jeffery W. Kelly, Gabriel C. Lander   +5 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source