Results 141 to 150 of about 120,581 (311)

Lactadherin binds to elastin - a starting point for medin amyloid formation?

, 2006
Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin.
Peng, Siwei, Gerwins, Par, Wassberg, Erik, Westermark, Per, Thelin, Stefan, Gerwins, Pär,, Abrams, William R., Wassberg, Erik,, Westermark, Per,, Persson, Helena, Larsson, Annika,, Larsson, Annika, Rosenbloom, Joel, Sletten, Knut, Peng, Siwei,, Persson, Helena,, Lund University., Thelin, Stefan,   +17 more
core   +1 more source

Evolving Pathology of Anaplastic Thyroid Carcinoma: Integrating Morphology, Immunohistochemistry, and Molecular Insights

Cancer Science, EarlyView.
Schematic overview of progression from differentiated thyroid carcinoma (DTC) to anaplastic thyroid carcinoma (ATC). ATC primarily develops via two pathways: the BRAF p.V600E‐mutated papillary thyroid carcinoma (PTC) pathway and the RAS‐mutated pathway. The origin and progression of BRAF/RAS‐wildtype ATC remain unclear.
Toru Odate, Tetsuo Kondo
wiley   +1 more source

Biomolecular studies in Alzheimer’s Disease models: investigations in vitro and in vivo

, 2013
The Alzheimer’s disease (AD), the most prevalent form of age-related dementia, is a multifactorial and heterogeneous neurodegenerative disease. The molecular mechanisms underlying the pathogenesis of AD are yet largely unknown.
Lattanzio, Francesca <1982>
core   +1 more source

Alteration in oral and non‐oral tissues in ligature‐induced periodontitis mice with the Alzheimer's disease risk factor APOE4

European Journal of Oral Sciences, EarlyView.
Abstract The APOE4 gene, particularly the ε4 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)‐α regulation on the combined effects remain unclear.
Ae Ri Kim, Yun‐Jung Yoo, Eun‐Jung Bak   +2 more
wiley   +1 more source

Influence of apolipoprotein E and its receptors on cere-bral amyloid precursor protein metabolism following

Chinese Journal of Traumatology, 2012
【Abstract】Traumatic brain injury (TBI) is the lead-ing cause of mortality and disability among young indi-viduals in our society, and globally the incidence of TBI is rising sharply. Mounting evidence has indicated that apolipoprotein E (apoE: protein;
ZHOU Shuai, SUN Xiao-chuan
doaj  

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

New capacities of the diagnosis and monitoring of the course of AL-amyloidosis

Терапевтический архив, 2010
Aim: to define the clinical value of various concentrations of immunoglobulin light chains (ILCs) in patients with AL amyloidosis. Subjects and methods.
V V Rameyev, L V Kozlovskaya, I N Kogarko, B S Kogarko   +3 more
doaj  

Plasma Aβ42 correlates positively with increased body fat in healthy individuals

, 2005
Obesity and overweight, well known risk factors for cardiovascular disease and type 2 diabetes, are now associated with Alzheimer's disease (AD). It remains to be determined if obesity and overweight contribute to the risk of developing AD through ...
Balakrishnana, K., Beilbye, J., Newton, Robert, Nolan, David, Martins, Ralph N., Newton, R., Mehta, P.D., Pankaj D. Mehta, David Nolan, Kelvin Balakrishnan, Galvão, Daniel A., Ralph N. Martins, Beilby, J., Gandy, Samuel E., Samuel E. Gandy, John Beilby, Giuseppe Verdile, Balakrishnan, Kelvin, Martins, R., Gandy, S., Verdile, G., Verdile, Giuseppe, Gandy, S.E., Galvao, D., Galvão, D.A., Nolan, D., Mehta, Pankaj D., Balakrishnan, K., Daniel A. Galvão, Beilby, John, Martins, R.N., Robert Newton, Mehta, P.   +32 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source