Results 161 to 170 of about 3,811,291 (280)

Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 Overexpression Abrogates ST6GAL1 Mediated Rectal Cancer Chemoradiation Resistance. [PDF]

Cancer Genomics Proteomics
Beamon TC, Mohammed ED, Lever JMP, Irwin RK, Somasundaram V, Huang F, McLeod MC, Hardiman KM.   +7 more
europepmc   +1 more source

Dual‐Component Spidroin‐Based Hydrogels: A Mechanically Tunable Platform for 2D and 3D Cell Culture

Small, EarlyView.
A dual‐component recombinant spider silk hydrogel platform was developed by combining NT2RepCT with a bioactive vitronectin‐functionalized spidroin domain. The hydrogels self‐assemble under physiological conditions, exhibit tunable mechanical properties, and support 2D and 3D cell culture, providing a versatile platform for mechanobiological studies ...
Sanna Korpela, Urmimala Chatterjee, Gabriele Greco, Benjamin Schmuck, Rakesh Kumar, Olga Shilkova, Cecilia Götherström, Anna Rising, Teemu O. Ihalainen   +8 more
wiley   +1 more source

A Cerebral Organoid Model of Familial Alzheimer's Disease Using Amyloid Precursor Protein Mutation, Val669Leu (<i>APP^Seoul</i>). [PDF]

Int J Stem Cells
Jung WH, Oh ST, Choe MS, Kwon YJ, Kim SJ, Jeon YS, Baek KM, Chang W, Lim KS, Kim JS, Yun SP, Lee MY.   +11 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation

Neural Regeneration Research, 2017
Sage Arbor
doaj   +1 more source

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level. [PDF]

Front Pharmacol
Petrushanko IY, Lisitskii DR, Strelkova MA, Tolstova AP, Fedulov AP, Filonov FA, Mitkevich VA, Makarov AA.   +7 more
europepmc   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

A synapse perspective on the function of the amyloid precursor protein. [PDF]

Sci Prog
Kruse P, Eichler A, Klukas L, Lenz M.
europepmc   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Molecular pathways underlying amyloid precursor protein-mediated regulation of adult-born neurons. [PDF]

Neural Regen Res
Hu H, Li H, Chen Y, Zhou J, Chen J, Tang Q, Chen X, Jiang J, Sun M, Jia D, Xie W, Long C, Yang L.   +12 more
europepmc   +1 more source