Results 161 to 170 of about 175,143 (304)

Alteration in oral and non‐oral tissues in ligature‐induced periodontitis mice with the Alzheimer's disease risk factor APOE4

European Journal of Oral Sciences, EarlyView.
Abstract The APOE4 gene, particularly the ε4 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)‐α regulation on the combined effects remain unclear.
Ae Ri Kim, Yun‐Jung Yoo, Eun‐Jung Bak   +2 more
wiley   +1 more source

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level. [PDF]

Front Pharmacol
Petrushanko IY, Lisitskii DR, Strelkova MA, Tolstova AP, Fedulov AP, Filonov FA, Mitkevich VA, Makarov AA.   +7 more
europepmc   +1 more source

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

Androgen Effects on Amyloid Precursor Protein Processing Pathways in Cancer: A Systematic Review. [PDF]

Curr Issues Mol Biol
Alhadrami M, Stone G, Barker RM, Palmer JC, Kehoe PG, Perks CM.   +5 more
europepmc   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Amyloid precursor protein (APP) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

TUNING PEPTIDES TO BIND TO THE AMYLOID PRECURSOR PROTEIN

IBRO Neuroscience Reports, 2023
Raquel Lopez-Rios De Castro, Christian Lorenz, Martin Ulmschneider   +2 more
doaj   +1 more source

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression [PDF]

, 2019
Bateman, Randall J.
core   +1 more source

Amyloid precursor protein (APP) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source