Results 151 to 160 of about 3,811,291 (280)

Diet-Induced Amyloid Precursor Protein Dysregulation in Kidney and Adipose Tissue Mediates Mitochondrial Dysfunction. [PDF]

Cells
Delport A, Ally E, Maharaj S, Hewer R.
europepmc   +1 more source

The Histidine 382 Residue Influences the Thermal Stability and Binding Propensity of the E2 Domain of Amyloid Precursor Protein

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The E2 domain of amyloid precursor protein (APP_E2) plays a central role in the protein's function. We reinvestigate how the missense mutation, ΔH382L, affects the domain's thermal stability and ligand binding propensity through differential scanning fluorometry.
Sphamandla Ndlovu, Candice Ngubane, Zamaxasibe Nxele, Raymond Hewer, Alexandré Delport   +4 more
wiley   +1 more source

Genome-Wide CRISPR Screening Identifies Genetic Modulators of Amyloid Precursor Protein Processing. [PDF]

Int J Mol Sci
Li Y, Yao Y, Xu Z, Xiong Y, Zhang C, Yu L, Gao H, Fei T.   +7 more
europepmc   +1 more source

Amyloid Precursor Protein Revisited [PDF]

Journal of Biological Chemistry, 2012
Qinxi Guo, Hongmei Li, Samson S.K. Gaddam, Nicholas J. Justice, Claudia S. Robertson, Hui Zheng   +5 more
openaire   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Amyloid precursor protein ortholog Appl acts with Vnd during mushroom body axon growth in Drosophila. [PDF]

Genetics
Marquilly C, Busto GU, Pasquer L, Zinzen RP, Hassan BA, Fradkin LG, Preat T, Boulanger A, Dura JM.   +8 more
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Mechanochemically Programmed, Oligomer‐Selective Amyloid Assembly via Axial Rotation

Small, EarlyView.
Tunable axial rotation mechanically redirects amyloid assembly without chemical additives. Low rotational speeds favor fibril maturation, whereas high‐speed rotation suppresses productive fibril amplification and biases the pathway toward oligomer‐enriched assemblies.
Seokbeom Roh, Eunji Song, Minwoo Bae, Da Yeon Cheong, Sechan Han, Taeha Lee, Dain Kang, Jae Eon Lee, Seung Pil Pack, Hyungbeen Lee, Insu Park, Gyudo Lee   +11 more
wiley   +1 more source

Self‐Assembly of Hierarchically Structured Materials From Liquid Crystalline Mesophases of Tobacco Mosaic Virus‐Like Particles

Small, EarlyView.
Recombinantly produced Tobacco Mosaic Virus coat protein (TMVcp) helical rods were demonstrated to reproducibly self‐assemble into hierarchically structured macroscopic filaments, driven by a lyotropic liquid crystal (LC) intermediate phase. The results indicate anisotropic molecular alignment of the fluid phase, retention of the native secondary ...
Guido M. Merino, Matthew J. Harrington, Amy Szuchmacher Blum   +2 more
wiley   +1 more source