Results 151 to 160 of about 120,581 (311)

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Impact of aging : sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease

, 2003
The identification of specific genetic (presenilin-1 [PS1] and amyloid precursor protein [APP] mutations) and environmental factors responsible for Alzheimer's disease (AD) has revealed evidence for a shared pathway of neuronal death.
Steiner, Barbara, Maurer, Konrad, Czech, Christian, Schindowski, Katharina, Leutner, Silke, Frölich, Lutz, Eckert, Anne, Pradier, Laurent, Kratzsch, Tilmann, Peters, Jürgen, Touchet, Natalie, Müller, Walter E.   +11 more
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Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Cognitive and Demographic Associations of Dementia‐Related Behavioural Changes in Adults With an Intellectual Disability: Findings From the IDS‐TILDA Study

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Individuals with intellectual disabilities (ID) are at an increased risk of developing dementia. Early detection is essential for providing appropriate support, yet identifying dementia‐related changes is challenging due to pre‐existing cognitive impairments.
Marie‐Joelle Beaudoin, Pavithra Pavithra, Mary McCarron, Philip McCallion, Antoinette O'Connnor, Sean Kennelly, Shoumitro Deb, Eimear McGlinchey   +7 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Studio della regolazione della maturazione proteolitica del precursore del peptide β amiloide APP

, 2006
[ITALIANO] Il peptide β amiloide presente nelle placche senili nella malattia di Alzheimer deriva dal taglio della proteina di membrana APP. In questo lavoro di tesi e’ stato sviluppato un sistema sperimentale per identificare possibili segnali ...
Gianni, Davide
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Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

The activity of amyloid beta binding alcohol dehydrogenase in Alzheimer's disease

, 2012
The mitochondria are a vibrant hub for many problems that occur in Alzheimer’s disease. The enzyme amyloid-ß binding alcohol dehydrogenase (ABAD) and Cyclophilin D (CypD) are two key mitochondrial proteins that have essential functions in Alzheimer’s ...
Allen, Zoe Eleanor
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