Results 101 to 110 of about 337,024 (290)

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. [PDF]

, 1989
Dmitry Goldgaber, H. Harris, Timothy Hla, T Maciag, Robert Donnelly, J. Steven Jacobsen, Michael P. Vitek, D. C. Gajdusek   +7 more
openalex   +1 more source

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments.

PLoS ONE, 2019
In a previous study, we reported that levels of two types of protein species-a type of ~55-kDa species and a type of ~15-kDa species-are elevated in the lumbar cerebrospinal fluid (CSF) of cognitively intact elderly individuals who are at risk for ...
Marianne K O Grant, Maureen Handoko, Malgorzata Rozga, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Karen H Ashe, Kathleen R Zahs, Peng Liu   +8 more
doaj   +1 more source

The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease

Frontiers in Neurology, 2017
Alzheimer’s disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system.
Juanjuan Zhao, Dongxu Yue, Ya Zhou, Li Jia, Hairong Wang, Mengmeng Guo, Hualin Xu, Chao Chen, Jidong Zhang, Lin Xu   +9 more
doaj   +1 more source

The PreA4₆₉₅precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons [PDF]

, 1989
H. G. Lemaire, J. Michael Salbaum, Gerd Multhaup, Jie Kang, Richard M. Bayney, Axel Unterbeck, Konrad Beyreuther, Benno Müller‐Hill   +7 more
openalex   +1 more source

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

Journal of Neuroscience, 2013
The development and progression of Alzheimer's disease is linked to excessive production of toxic amyloid-β peptide, initiated by β-secretase cleavage of the amyloid precursor protein (APP).
Camilla Gustafsen, Simon Glerup, L. T. Pallesen, Ditte Olsen, O. Andersen, A. Nykjær, P. Madsen, C. Petersen   +7 more
semanticscholar   +1 more source

Redundancy and divergence in the amyloid precursor protein family

FEBS Letters, 2013
Gene duplication provides genetic material required for functional diversification. An interesting example is the amyloid precursor protein (APP) protein family. The APP gene family has experienced both expansion and contraction during evolution. The three mammalian members have been studied quite extensively in combined knock out models.
S. Ali M. Shariati, Bart De Strooper
openaire   +3 more sources

Amyloid pathology in the brain after ischemia

Folia Neuropathologica, 2019
As the population is aging all over the world, the economic burden of ischemic brain injuries is constantly increasing. Human brain ischemia is one of the leading causes of premature death, significant morbidity and physical and mental disabilities ...
Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław Czuczwar   +3 more
doaj   +1 more source

SYSTEMIC AMYLOIDOSIS: FINDING ON AUTOPSY. REPORT OF TWO CASES (IN SPANISH)

Revista Ciencias Biomédicas, 2014
Introduction: amyloidosis is the extracellular accumulation of amyloid material, which causes damage in the functioning of organs and tissues. It is characterized by the presence of protein folding, which acquire the capacity of self-assembly creating
Martínez-Muñoz Elsa, Baena-Del Valle Javier, Barrios-Barreto Rina, Herrera-Lomonaco Sandra, Redondo-Bermúdez César, Miranda-Marzola María del Carmen   +5 more
doaj  

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant   +8 more
doaj   +1 more source

Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP

Nature Communications, 2017
Studying the physiological confirmation of amyloid β (Aβ) and amyloid precursor protein (APP) often uses techniques that could disrupt their conformation. Here, the authors use non-destructive microscopy approaches to study the confirmation of Aβ and APP
O. Klementieva, K. Willén, I. Martinsson, B. Israelsson, A. Engdahl, J. Cladera, P. Uvdal, G. K. Gouras   +7 more
doaj   +1 more source