Results 111 to 120 of about 337,024 (290)

Targeting Iron Responsive Elements (IREs) of APP mRNA into Novel Therapeutics to Control the Translation of Amyloid-β Precursor Protein in Alzheimer’s Disease

Pharmaceuticals
The hallmark of Alzheimer’s disease (AD) is the buildup of amyloid-β (Aβ), which is produced when the amyloid precursor protein (APP) misfolds and deposits as neurotoxic plaques in the brain.
Mateen A. Khan
doaj   +1 more source

Characterization of platelet-releasable forms of beta-amyloid precursor proteins: the effect of thrombin [PDF]

, 1992
RP Smith, GJ Jr Broze
openalex   +1 more source

Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]

, 2010
A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan, Deepa Gopakumar, Krishnan Namboori, Premkumar P, Radhagayathri K.U., Ramachandran K.I., Varun Gopal, Vasavi C.S.   +7 more
core   +1 more source

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. [PDF]

, 1991
Mark J. Adler, Carlos E. Coronel, Earl R. Shelton, J. Edwin Seegmiller, Nazneen N. Dewji   +4 more
openalex   +1 more source

Secretory cleavage site of Alzheimer amyloid precursor protein is heterogeneous in Down's syndrome brain [PDF]

, 1994
Fuyuki Kametania, Kikuko Tanaka, Takahiko Tokuda, Shu‐ichi Ikeda   +3 more
openalex   +1 more source

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor- and Cygb-associated signaling pathways

Neural Regeneration Research
A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer’s disease. Consequently, enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression ...
Biao Xiao, Chaoyang Chu, Zhicheng Lin, Tianyuan Fang, Yuyu Zhou, Chuxia Zhang, Jianghui Shan, Shiyu Chen, Liping Li   +8 more
doaj   +1 more source

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Science, 1999
R. Vassar, B. Bennett, S. Babu-Khan, S. Kahn, E. Mendiaz, P. Denis, D. Teplow, Sandra L. Ross, P. Amarante, R. Loeloff, Yi Luo, S. Fisher, J. Fuller, S. Edenson, J. Lile, M. Jarosinski, A. Biere, E. Curran, T. Burgess, J. Louis, F. Collins, J. Treanor, Gary Rogers, M. Citron   +23 more
semanticscholar   +1 more source

Amyloid precursor protein processing and Alzheimer's disease.

Annual Review of Neuroscience, 2011
Richard O'Brien, P. Wong
semanticscholar   +1 more source

Potential Role of Protease Nexin‐2/Amyloid β‐Protein Precursor as a Cerebral Anticoagulant^a [PDF]

, 1992
William E. Van Nostrand, Alvin H. Schmaier, Steven L. Wagner   +2 more
openalex   +1 more source