Results 41 to 50 of about 252,333 (374)
Journal of Biological Chemistry, 2017 Most cases of Alzheimer's disease (AD) are sporadic, but a small percentage of AD cases, called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the amyloid precursor protein.
A. Hatami +3 more
semanticscholar +1 more source
Amyloid precursor protein induces reactive astrogliosis
Acta Physiologica, 2023 AbstractAimAstrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role
Gretsen Velezmoro Jauregui +20 more
openaire +6 more sources
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα
Frontiers in Molecular Neuroscience, 2017 Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα ...
B. Mockett +3 more
semanticscholar +1 more source
Interactions between amyloid, amyloid precursor protein, and mitochondria
Biochemical Society Transactions, 2023 Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria.
openaire +2 more sources
A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase
Communications Biology, 2022 Thermodynamic analysis from unbiased molecular dynamics and bias-exchange metadynamics simulations reveals possible mechanisms on how γ-secretase cleaves the transmembrane domains of amyloid precursor protein into amyloid-β peptides.
Xiaoli Lu, Jing Huang
doaj +1 more source
Bio-Protocol, 2017 Alzheimer’s disease’s established primary trigger is β-amyloid (Aβ) (Mucke and Selkoe, 2012). The amyloid precursor protein (APP) endocytosis is required for Aβ generation at early endosomes (Rajendran and Annaert, 2012).
Florent Ubelmann +2 more
doaj +1 more source
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1 [PDF]
Journal of Biological Chemistry, 2004 Site-specific proteolysis of the amyloid-beta precursor protein (APP) by BACE 1 and gamma-secretase, a central event in Alzheimer disease, releases a large secreted extracellular fragment (called APP(S)), peptides of 40-43 residues derived from extracellular and transmembrane sequences (Abeta), and a short intracellular fragment (APP intracellular ...
Qiming Li, Thomas C. Südhof
openaire +3 more sources
Succinct Amyloid and Non-Amyloid Patterns in Hexapeptides [PDF]
arXiv, 2022 Hexapeptides are widely applied as a model system for studying amyloid-forming properties of polypeptides, including proteins. Recently, large experimental databases have become publicly available with amyloidogenic labels. Using these datasets for training and testing purposes, one may build artificial intelligence (AI)-based classifiers for ...
arxiv
Bangladesh Journal of Pharmacology, 2016 The aim of this study was to assess the potential of amyloid precursor protein in peripheral granulocytes as a diagnostic biomarker for early detection of Alzheimer’s disease.
Xiaonan Wang +4 more
doaj +2 more sources
Tau post-translational modifications in wildtype and human amyloid precursor protein transgenic mice
Nature Neuroscience, 2015 The microtubule-associated protein tau has been implicated in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Reducing tau levels ameliorates AD-related synaptic, network, and behavioral abnormalities in transgenic ...
Meaghan Morris +6 more
semanticscholar +1 more source