Results 51 to 60 of about 337,024 (290)

Amyloid precursor protein induces reactive astrogliosis

Acta Physiologica, 2023
AbstractAimAstrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role
Gretsen Velezmoro Jauregui, Dragana Vukić, Isaac G. Onyango, Carlos Arias, Jan S. Novotný, Kateřina Texlová, Shanshan Wang, Kristina Locker Kovačovicova, Natalie Polakova, Jana Zelinkova, Maria Čarna, Valentina Lacovich Strašil, Brian P. Head, Daniel Havas, Martin Mistrik, Robert Zorec, Alexei Verkhratsky, Liam Keegan, Mary O’Connel, Robert Rissman, Gorazd B. Stokin   +20 more
openaire   +6 more sources

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis *

Journal of Biological Chemistry, 2016
Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β.
Robert J Andrew, K. Kellett, G. Thinakaran, N. Hooper   +3 more
semanticscholar   +1 more source

A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase

Communications Biology, 2022
Thermodynamic analysis from unbiased molecular dynamics and bias-exchange metadynamics simulations reveals possible mechanisms on how γ-secretase cleaves the transmembrane domains of amyloid precursor protein into amyloid-β peptides.
Xiaoli Lu, Jing Huang
doaj   +1 more source

A global disorder of imprinting in the human female germ line [PDF]

, 2002
Imprinted genes are expressed differently depending on whether they are carried by a chromosome of maternal or paternal origin. Correct imprinting is established by germline-specific modifications; failure of this process underlies several inherited ...
A Kerjean, BE Hayward, BE Hayward, BE Hayward, Bruce E. Hayward, D Bourc’his, David T. Bonthron, Eamonn Sheridan, Hannah Judson, J Liu, J Liu, JS Sutcliffe, K Buiting, L Strain, M Kamiya, MN Helwani, MP Lee, NJ Smilinich, O El-Maarri, R Shemer, RA Fisher, RJ Gardner, S Engemann, SJ Clark, SK Murphy, T Kajii, T Kaneko-Ishino, T Ohta, W Reik, W Reik, YB Moglabey   +30 more
core   +1 more source

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

Frontiers in Molecular Neuroscience, 2017
Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα ...
B. Mockett, Max Richter, W. Abraham, U. Müller   +3 more
semanticscholar   +1 more source

A Novel Protocol to Quantitatively Measure the Endocytic Trafficking of Amyloid Precursor Protein (APP) in Polarized Primary Neurons with Sub-cellular Resolution

Bio-Protocol, 2017
Alzheimer’s disease’s established primary trigger is β-amyloid (Aβ) (Mucke and Selkoe, 2012). The amyloid precursor protein (APP) endocytosis is required for Aβ generation at early endosomes (Rajendran and Annaert, 2012).
Florent Ubelmann, Tatiana Burrinha, Cláudia Guimas Almeida   +2 more
doaj   +1 more source

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide*

Journal of Biological Chemistry, 2017
Most cases of Alzheimer's disease (AD) are sporadic, but a small percentage of AD cases, called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the amyloid precursor protein.
A. Hatami, Sanaz Monjazeb, S. Milton, C. Glabe   +3 more
semanticscholar   +1 more source

Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1 [PDF]

Journal of Biological Chemistry, 2004
Site-specific proteolysis of the amyloid-beta precursor protein (APP) by BACE 1 and gamma-secretase, a central event in Alzheimer disease, releases a large secreted extracellular fragment (called APP(S)), peptides of 40-43 residues derived from extracellular and transmembrane sequences (Abeta), and a short intracellular fragment (APP intracellular ...
Qiming Li, Thomas C. Südhof
openaire   +3 more sources

Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimer’s disease

Bangladesh Journal of Pharmacology, 2016
The aim of this study was to assess the potential of amyloid precursor protein in peripheral granulocytes as a diagnostic biomarker for early detection of Alzheimer’s disease.
Xiaonan Wang, Xihai Li, Jie Yang, Ming Yu, Jinmei Wu   +4 more
doaj   +2 more sources