Results 51 to 60 of about 82,488 (290)

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

TRANSTHYRETIN POLYNEUROPATHY (CLINICAL CASE)

Медицина в Кузбассе, 2023
Amyloidosis is a violation of protein metabolism, accompanied by the formation in tissues of a specific protein-polysaccharide complex (amyloid) of a fibrillar structure, characterized by a high orderliness of fibrils 5-10 nm thick due to the abundance ...
Наталья Викторовна Коробкова, Светлана Алексеевна Зуева, Ольга Валерьевна Рохленко, Вадим Гельевич Мозес, Елена Владимировна Рудаева, Светлана Ивановна Елгина, Кира Борисовна Мозес, Яэль Центер, Наталья Степановна Черных   +8 more
doaj  

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

The Role of Artificial Intelligence in Advancing Biosensor Technology: Past, Present, and Future Perspectives

Advanced Materials, EarlyView.
This review explores the transformative role of AI in biosensor technology and provides a holistic interdisciplinary perspective that covers a broader scope of AI‐enabled biosensor technologies across various sectors including healthcare, environmental monitoring, food safety, and agriculture. It also highlights the important role of novel materials in
Tuğba Akkaş, Mahshid Reshadsedghi, Mustafa Şen, Volkan Kılıç, Nesrin Horzum   +4 more
wiley   +1 more source

Data on thrombotic ischemic lesions in the presence or absence of amyloid ß-protein precursor or its homolog amyloid precursor-like protein-2 in mice

Data in Brief, 2016
Amyloid ß-protein precursor (AßPP) and amyloid precursor-like protein-2 (APLP2) are potent inhibitors of thrombosis, see related article “The influence of the amyloid ß-protein and its precursor in modulating cerebral thrombosis” (Van Nostrand, 2016) [1].
Feng Xu, William E. Van Nostrand
doaj  

Stimuli‐Responsive Materials for Biomedical Applications

Advanced Materials, EarlyView.
Stimulus‐responsive materials (SRMs) hold great promise for use in a wide range of biomedical applications. This review covers four stimulus modalities, namely, electrical, optical, magnetic, and ultrasound, and their associated SRMs. It provides a summary of the materials in each modality, their development, and current research perspectives.
Adriana Teixeira do Nascimento, Paul R. Stoddart, Toon Goris, Miriam Kael, Richard Manasseh, Karen Alt, Jurie Tashkandi, Byung Chul Kim, Simon E Moulton   +8 more
wiley   +1 more source

Copper Promotes the Trafficking of the Amyloid Precursor Protein [PDF]

Journal of Biological Chemistry, 2011
Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (APP). We reported previously that copper increases the level of APP at the cell surface.
Ashley I. Bush, Qiao-Xin Li, Andrew H. Dalziel, Alan Rembach, Alan Rembach, Karla M. Acevedo, Krutika Wikhe, Colin L. Masters, Ya Hui Hung, Katrina M. Laughton, Blaine R. Roberts, James Camakaris   +11 more
openaire   +4 more sources

3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine

Advanced Materials, EarlyView.
This perspective article discusses how 3D bioprinting is advancing the development of neural tissue models and implants. It highlights recent progress in fabricating complex, multicellular neural constructs, examines current technical barriers, and outlines future applications in disease modeling, neurotoxicity testing, and regenerative therapies ...
Mitchell St Clair‐Glover, Zhilian Yue, Mirella Dottori   +2 more
wiley   +1 more source

NeuroAiD® (MLC601) and Amyloid Precursor Protein Processing [PDF]

Cerebrovascular Diseases, 2013
<b><i>Background:</i></b> Amyloid precursor protein (APP) undergoes cleavage under physiological conditions, predominantly by α- and &#947;-secretases, to form the nonpathogenic sAPPα and p3 fragments. By contrast, amyloid-beta (Aβ) is produced via proteolytic cleavage by β- and &#947;-secretases. In Alzheimer's disease (
Lim, YA, Murray, LA, Lai, MKP, Chen, C
openaire   +3 more sources