Results 61 to 70 of about 337,024 (290)
Journal of Pharmacological Sciences, 2012 Neuregulin-1 (NRG1) plays important roles in the development and plasticity of the brain, and it is also reported to have potent neuroprotective properties.
Junghwa Ryu +6 more
doaj +1 more source
Integrated dataset on acute phase protein response in chicken challenged with Escherichia coli lipopolysaccharide endotoxin [PDF]
, 2018 Data herein describe the quantitative changes in the plasma proteome in chickens challenged with lipopolysaccharide (LPS), a bacterial endotoxin known to stimulate the host innate immune system obtained by shotgun quantitative proteomic tandem mass tags ...
Bain, Maureen +7 more
core +2 more sources
Neural Regeneration Research, 2016 Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit ...
Yong-lin Zhao +5 more
doaj +1 more source
Scientific Reports, 2021 Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (amyloid precursor
Justin L. Tosh +12 more
doaj +1 more source
Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice [PDF]
, 2007 The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related Abeta aggregates have been described in a variety of vertebrate animals, with the notable exception of mice and rats.
Borchelt, David R. +7 more
core +2 more sources
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. [PDF]
, 2011 Sanfilippo syndrome type B (MPS IIIB) is characterized by profound mental retardation in childhood, dementia and death in late adolescence; it is caused by deficiency of α-N-acetylglucosaminidase and resulting lysosomal storage of heparan sulfate.
Neufeld, Elizabeth F +2 more
core +5 more sources
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice [PDF]
, 2012 Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease).
Alex J. Harper +62 more
core +4 more sources
Tau post-translational modifications in wildtype and human amyloid precursor protein transgenic mice
Nature Neuroscience, 2015 The microtubule-associated protein tau has been implicated in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Reducing tau levels ameliorates AD-related synaptic, network, and behavioral abnormalities in transgenic ...
Meaghan Morris +6 more
semanticscholar +1 more source
Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins [PDF]
, 2018 Significant advances in the understanding of the molecular determinants of fibrillogenesis can be expected from comparative studies of the aggregation propensities of proteins with highly homologous structures but different folding pathways.
Baglivo, I +18 more
core +2 more sources
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Neurobiology of Disease, 2009 Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in gene transcriptional control, could be involved in the development of sporadic Alzheimer's disease (AD ...
Sébastien S. Hébert +6 more
doaj +1 more source