Results 61 to 70 of about 252,333 (374)

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer’s Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways

Pharmaceuticals
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with age. A wealth of evidence indicates that the amyloid β (Aβ) aggregates result from dyshomeostasis between Aβ production and clearance, which plays a pivotal role in the pathogenesis
Xinhua Zhou, Zeyu Zhu, Shaoming Kuang, Kaipeng Huang, Yueping Li, Yuqiang Wang, Haiyun Chen, Maggie Pui Man Hoi, Benhong Xu, Xifei Yang, Zaijun Zhang   +10 more
doaj   +1 more source

How to Manufacture Photonic Metamaterials

Advanced Materials Technologies, EarlyView.
Metamaterials boast applications such as invisibility and “hyperlenses” with resolution beyond the diffraction limit, but these applications haven’t been exploited in earnest and the market for them hasn’t grown much likely because facile and economical methods for fabricating them without defect has not emerged.
Apurba Paul, Gregory Timp
wiley   +1 more source

Multifunctional Fibrous Mats: Stretchable, Conductive, and Hydrophilic Platforms for Wearable Electronics

Advanced Materials Technologies, EarlyView.
A hydrophilic, stretchable, nonwoven electrospun fiber mat targeted to be applied in long‐term bioelectronic devices. By incorporating amphiphilic polyethylene glycol block copolymers in a polydimethylsiloxane matrix, the material develops stable hydrophilicity, enhanced breathability, as well as enhanced adhesion to cells.
Joab S. Dorsainvil, Jafar Batayneh, Maya McDonald, Natalie Pachter, Serena Patel, Dana Manashirov, Tracy Hookway, Ahyeon Koh   +7 more
wiley   +1 more source

Electrostatics in the Stability and Misfolding of the Prion Protein: Salt Bridges, Self-Energy, and Solvation [PDF]

Biochemistry and Cell Biology 2010, Volume 88, Number 2, Pages 371 - 381, 2010
Using a recently developed mesoscopic theory of protein dielectrics, we have calculated the salt bridge energies, total residue electrostatic potential energies, and transfer energies into a low dielectric amyloid-like phase for 12 species and mutants of the prion protein.
arxiv   +1 more source

TRANSTHYRETIN POLYNEUROPATHY (CLINICAL CASE)

Medicina v Kuzbasse, 2023
Amyloidosis is a violation of protein metabolism, accompanied by the formation in tissues of a specific protein-polysaccharide complex (amyloid) of a fibrillar structure, characterized by a high orderliness of fibrils 5-10 nm thick due to the abundance ...
Наталья Викторовна Коробкова, Светлана Алексеевна Зуева, Ольга Валерьевна Рохленко, Вадим Гельевич Мозес, Елена Владимировна Рудаева, Светлана Ивановна Елгина, Кира Борисовна Мозес, Яэль Центер, Наталья Степановна Черных   +8 more
doaj  

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Cell & Bioscience, 2023
Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and AD pathology ...
Vladimir Rudajev, Jiri Novotny
doaj   +1 more source

Mechanochemistry: Fundamental Principles and Applications

Advanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong, Luofei Li, Huiyan Chen, Yi Cao, Hai Lei   +4 more
wiley   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Insights into the variability of nucleated amyloid polymerization by a minimalistic model of stochastic protein assembly [PDF]

, 2015
Self-assembly of proteins into amyloid aggregates is an important biological phenomenon associated with human diseases such as Alzheimer's disease. Amyloid fibrils also have potential applications in nano-engineering of biomaterials. The kinetics of amyloid assembly show an exponential growth phase preceded by a lag phase, variable in duration as seen ...
arxiv   +1 more source